3-Bromo-2-chloroquinoline

Basic Information

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CAS Number

101870-60-4

Molecular Formula

C9H5BrClN

Molecular Weight

242.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1=CC=C2C(=C1)C=C(C(=N2)Cl)Br

InChI

InChI=1S/C9H5BrClN/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5H

InChIKey

RWWUFTQVKMNRQN-UHFFFAOYSA-N

LogP

3.6507000000000005

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

165

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

DTXSID60459131
3-BROMO-2-CHLOROQUINOLINE
AKOS005257081
AS-33662
SY096879
FT-0682317
A16297
EN300-258136
101870-60-4
W-204433
BEA87060
PB20265
MFCD08457743
RWWUFTQVKMNRQN-UHFFFAOYSA-N
SCHEMBL1767846
CS-0051485
QUINOLINE, 3-BROMO-2-CHLORO-
3-bromo-2-chloro-quinoline
3-Bromo-2-chloroquinoline
Quinoline,3-bromo-2-chloro-
2-Chlor-3-brom-chinolin
2-CHLORO-3-BROMOQUINOLINE
3-Brom-2-chlor-chinolin
QUINOLINE,3-BROMO-2-CHLORO
RP05906
FCH1388940
AX8084924
AB0039360
Y6812
3-bromo-2-chloroquinoline

MDL Number

MFCD08457743

Customs Code

2933499090

FAQ

What are the physical and chemical properties of 3-Bromo-2-chloroquinoline (CAS: 101870-60-4)?

3-Bromo-2-chloroquinoline (CAS: 101870-60-4) is a crystalline solid with a molecular weight of approximately 250.02 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and acetone. Chemically, it is highly reactive and can undergo substitution reactions easily. It is also susceptible to hydrolysis under basic conditions.

How is 3-Bromo-2-chloroquinoline (CAS: 101870-60-4) typically synthesized?

3-Bromo-2-chloroquinoline (CAS: 101870-60-4) is commonly synthesized via halogenation of quinoline with bromine and chlorine in the presence of a base such as sodium hydroxide. The reaction is carried out under anhydrous conditions to avoid side reactions. The yield and selectivity can be optimized by controlling the reaction temperature and the ratio of reactants.

What industries use 3-Bromo-2-chloroquinoline (CAS: 101870-60-4)?

3-Bromo-2-chloroquinoline (CAS: 101870-60-4) is primarily used in the pharmaceutical industry for the synthesis of various drug intermediates. It also finds applications in the chemical industry for the production of dyes and other organic compounds. Additionally, it is used in the research of new sensor technologies and as a precursor in semiconductor manufacturing processes.

What precautions should be taken when handling 3-Bromo-2-chloroquinoline (CAS: 101870-60-4)?

When handling 3-Bromo-2-chloroquinoline (CAS: 101870-60-4), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or fume hood to avoid inhalation. Spills should be immediately cleaned up using appropriate procedures, and the material safety data sheet (MSDS) should be consulted for detailed safety information.