2-Chloro-N-(2-nitrophenyl)acetamide

Basic Information

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CAS Number

10147-70-3

Molecular Formula

C8H7ClN2O3

Molecular Weight

214.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

91-92°C

SMILES

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C1=CC=C(C(=C1)NC(=O)CCl)[N+](=O)[O-]

InChI

InChI=1S/C8H7ClN2O3/c9-5-8(12)10-6-3-1-2-4-7(6)11(13)14/h1-4H,5H2,(H,10,12)

InChIKey

XXWVCPLQFJVURO-UHFFFAOYSA-N

LogP

2.36830

Complexity

229

Safety Information

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Hazard Statement

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

SCHEMBL4002217
2-Chloro-N-(2-nitrophenyl)ethanimidic acid
EN300-16918
A inverted exclamation mark-Chloro-2-nitroacetanilide
Acetamide,2-chloro-N-(2-nitrophenyl)-
2-chloro-N-(2-nitrophenyl)acetamide
MFCD00024201
UPCMLD0ENAT0507-3481:001
2-CHLORO-2'-NITROACETANILIDE
N-(2-nitrophenyl)-2-chloroacetamide
NSC8365
AKOS000294925
2-Nitro-N-(chloroacetyl)aniline
JS-101C
FT-0636641
AKOS015912956
DTXSID10906206
NSC-8365
CS-0034970
o-nitro-alpha-chloroacetanilide
Z56822452
10147-70-3
Acetamide, 2-chloro-N-(2-nitrophenyl)-
Alpha-Chloro-2-Nitroacetanilide
E79346
2-Chloro-2-nitroacetanilide
NSC 8365
XXWVCPLQFJVURO-UHFFFAOYSA-N
ALPHA-CHLORO-2-NITROACETANILIDE
ó-chloro-2-nitroacetanilide

MDL Number

MFCD00024201

Customs Code

2924299090

FAQ

What are the physical and chemical properties of 2-Chloro-N-(2-nitrophenyl)acetamide (CAS: 10147-70-3)?

2-Chloro-N-(2-nitrophenyl)acetamide (CAS: 10147-70-3) is a solid with a crystalline form. It has a molecular weight of approximately 222.63 g/mol. This compound is slightly soluble in water and more soluble in organic solvents such as methanol and ethanol. Chemically, it is stable under normal conditions but reacts with bases to produce chloroacetamide and 2-nitrophenol. It is commonly used in organic synthesis and as an intermediate in the production of other chemicals.

How is 2-Chloro-N-(2-nitrophenyl)acetamide (CAS: 10147-70-3) typically synthesized?

2-Chloro-N-(2-nitrophenyl)acetamide (CAS: 10147-70-3) is typically synthesized by the reaction of 2-nitrophenyl acetate with hydrochloric acid. This synthesis involves the nucleophilic substitution of the hydroxyl group by chloride ion. The reaction yields a high purity product with a yield of around 75-80%. The use of appropriate solvents and temperature control can enhance the selectivity and yield of the reaction.

What industries use 2-Chloro-N-(2-nitrophenyl)acetamide (CAS: 10147-70-3)?

2-Chloro-N-(2-nitrophenyl)acetamide (CAS: 10147-70-3) is used in various industries. It is a key intermediate in the pharmaceutical industry for the synthesis of certain drugs. It is also used in the production of organic dyes, as a precursor in the polymer industry, and in analytical chemistry for the preparation of reagents. Its role in semiconductors and sensors is less common but it can be utilized in these areas for specialized applications.

What precautions should be taken when handling 2-Chloro-N-(2-nitrophenyl)acetamide (CAS: 10147-70-3)?

When handling 2-Chloro-N-(2-nitrophenyl)acetamide (CAS: 10147-70-3), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Use a fume hood to minimize exposure to chlorinated compounds. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage. This compound, while stable under normal conditions, may react with strong bases, so care should be taken to avoid these conditions.