2-Chloro-N-(2-nitrophenyl)acetamide(CAS: 10147-70-3)

2-Chloro-N-(2-nitrophenyl)acetamide (CAS: 10147-70-3) is a solid with a crystalline form. It has a molecular weight of approximately 222.63 g/mol. This compound is slightly soluble in water and more soluble in organic solvents such as methanol and ethanol. Chemically, it is stable under normal conditions but reacts with bases to produce chloroacetamide and 2-nitrophenol. It is commonly used in organic synthesis and as an intermediate in the production of other chemicals.

2-Chloro-N-(2-nitrophenyl)acetamide (CAS: 10147-70-3) is typically synthesized by the reaction of 2-nitrophenyl acetate with hydrochloric acid. This synthesis involves the nucleophilic substitution of the hydroxyl group by chloride ion. The reaction yields a high purity product with a yield of around 75-80%. The use of appropriate solvents and temperature control can enhance the selectivity and yield of the reaction.

2-Chloro-N-(2-nitrophenyl)acetamide (CAS: 10147-70-3) is used in various industries. It is a key intermediate in the pharmaceutical industry for the synthesis of certain drugs. It is also used in the production of organic dyes, as a precursor in the polymer industry, and in analytical chemistry for the preparation of reagents. Its role in semiconductors and sensors is less common but it can be utilized in these areas for specialized applications.

When handling 2-Chloro-N-(2-nitrophenyl)acetamide (CAS: 10147-70-3), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Use a fume hood to minimize exposure to chlorinated compounds. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage. This compound, while stable under normal conditions, may react with strong bases, so care should be taken to avoid these conditions.