2-(4-Nitrophenyl)ethanol | CAS No. 100-27-6

Q: What are the physical and chemical properties of 2-(4-Nitrophenyl)ethanol (CAS: 100-27-6)?

2-(4-Nitrophenyl)ethanol (CAS: 100-27-6) is a colorless to light yellow liquid with a molecular weight of approximately 198.14 g/mol. It has a density of about 1.08 g/cm³ and a boiling point of around 188°C. This compound is moderately soluble in water and readily soluble in organic solvents like ethanol and acetone. It is not highly reactive under normal conditions but can undergo nitro reduction.

Q: How is 2-(4-Nitrophenyl)ethanol (CAS: 100-27-6) typically synthesized?

2-(4-Nitrophenyl)ethanol (CAS: 100-27-6) is synthesized by the nitration of 2-phenylethanol followed by reduction of the nitro group to an amino group and then to an alcohol. Common reagents used include nitric acid in the presence of sulfuric acid. The process involves careful control of temperature and concentration to achieve high yield and selectivity.

Q: What industries use 2-(4-Nitrophenyl)ethanol (CAS: 100-27-6)?

2-(4-Nitrophenyl)ethanol (CAS: 100-27-6) is primarily used in the pharmaceutical industry as an intermediate in drug synthesis. It is also utilized in the production of various dyes and pigments, and can be found in some polymer formulations and as a component in certain sensors and semiconductors.

Q: What precautions should be taken when handling 2-(4-Nitrophenyl)ethanol (CAS: 100-27-6)?

When handling 2-(4-Nitrophenyl)ethanol (CAS: 100-27-6), ensure appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation. Store in a cool, dry place away from direct sunlight and heat sources. In case of spill, immediately clean up using appropriate materials and consult the Safety Data Sheet (SDS) for detailed emergency procedures.

2-(4-Nitrophenyl)ethanol

Basic Information

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CAS Number

100-27-6

Molecular Formula

C8H9NO3

Molecular Weight

167.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

59.0 to 63.0 deg-C

Boiling Point

148°C/2mmHg

Water Solubility

<0.01 g/100 mL at 18 ºC

Flash Point

144.5°C

Refractive Index

1.5570 (estimate)

SMILES

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C1=CC(=CC=C1CCO)[N+](=O)[O-]

InChI

InChI=1S/C8H9NO3/c10-6-5-7-1-3-8(4-2-7)9(11)12/h1-4,10H,5-6H2

InChIKey

IKMXRUOZUUKSON-UHFFFAOYSA-N

LogP

1.65280

Complexity

147

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Stability

Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.

Synonyms & References

English

FT-0608686
MFCD00010202
2-(p-nitrophenyl) ethanol
PS-4048
Phenethyl alcohol, p-nitro-
Z276600186
4-Nitrophenethyl alcohol
P-NITROPHENETHYL ALCOHOL
NCGC00091653-01
NCGC00091653-02
2-(4-nitrophenyl)ethan-1-ol
SCHEMBL250473
2-(4-Nitrophenyl)ethanol
4-nitrobenzene-ethanol
DTXSID7025764
EINECS 202-835-8
NSC 55519
4-Nitro-benzeneethanol
W-108971
100-27-6
AKOS 90322
Tox21_200285
N0569
AMY14610
CAS-100-27-6
Benzeneethanol, 4-nitro-
Oprea1_314753
CK2458
NS00022963
NSC-55519
2-(4-nitro-phenyl)-ethanol

MDL Number

MFCD00010202

Customs Code

2906299090

FAQ

What are the physical and chemical properties of 2-(4-Nitrophenyl)ethanol (CAS: 100-27-6)?

2-(4-Nitrophenyl)ethanol (CAS: 100-27-6) is a colorless to light yellow liquid with a molecular weight of approximately 198.14 g/mol. It has a density of about 1.08 g/cm³ and a boiling point of around 188°C. This compound is moderately soluble in water and readily soluble in organic solvents like ethanol and acetone. It is not highly reactive under normal conditions but can undergo nitro reduction.

How is 2-(4-Nitrophenyl)ethanol (CAS: 100-27-6) typically synthesized?

2-(4-Nitrophenyl)ethanol (CAS: 100-27-6) is synthesized by the nitration of 2-phenylethanol followed by reduction of the nitro group to an amino group and then to an alcohol. Common reagents used include nitric acid in the presence of sulfuric acid. The process involves careful control of temperature and concentration to achieve high yield and selectivity.

What industries use 2-(4-Nitrophenyl)ethanol (CAS: 100-27-6)?

2-(4-Nitrophenyl)ethanol (CAS: 100-27-6) is primarily used in the pharmaceutical industry as an intermediate in drug synthesis. It is also utilized in the production of various dyes and pigments, and can be found in some polymer formulations and as a component in certain sensors and semiconductors.

What precautions should be taken when handling 2-(4-Nitrophenyl)ethanol (CAS: 100-27-6)?

When handling 2-(4-Nitrophenyl)ethanol (CAS: 100-27-6), ensure appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation. Store in a cool, dry place away from direct sunlight and heat sources. In case of spill, immediately clean up using appropriate materials and consult the Safety Data Sheet (SDS) for detailed emergency procedures.