(+)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETIC ANHYDRIDE(CAS: 85541-57-7)

The compound is an anhydride with a crystalline form. Its molecular weight is approximately 295.25 g/mol. It is poorly soluble in water but soluble in organic solvents like dichloromethane and acetonitrile. Chemically, it is reactive, particularly in esterification and amidation reactions. It is stable under normal conditions but requires handling with care due to its reactivity.

This compound is typically synthesized through the condensation of alpha-methoxy-alpha-(trifluoromethyl)phenylacetic acid with an anhydride-forming reagent. Common methods include the use of phosgene or acetic anhydride. The reaction is conducted under anhydrous conditions to prevent hydrolysis. The yield is generally good, with selectivity towards the desired anhydride product.

This compound is used in the pharmaceutical industry for the synthesis of pharmaceutical intermediates. It is also used in the polymer industry for modifying polymer properties. Additionally, it finds application in the sensor and semiconductor industries for specific chemical modifications and derivatizations.

When handling this compound, use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a fume hood to avoid inhalation or skin contact. Spills should be handled with care using absorbent materials, and the area should be flushed with water. Refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.