(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Anhydride

Basic Information

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CAS Number

85541-57-7

Molecular Formula

C20H16F6O5

Molecular Weight

450.33 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

48°C

Refractive Index

77.5 ° (C=2, CHCl3)

SMILES

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COC(C1=CC=CC=C1)(C(=O)OC(=O)C(C2=CC=CC=C2)(C(F)(F)F)OC)C(F)(F)F

InChI

InChI=1S/C20H16F6O5/c1-29-17(19(21,22)23,13-9-5-3-6-10-13)15(27)31-16(28)18(30-2,20(24,25)26)14-11-7-4-8-12-14/h3-12H,1-2H3

InChIKey

AATFPUCRBIXXID-UHFFFAOYSA-N

LogP

4.264600000000002

Topological Polar Surface Area

61.83 Å²

Hydrogen Bond Donor/Acceptor

0 / 5

Complexity

583

Synonyms & References

English

85541-57-7
(3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl) 3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
AKOS015851436
AATFPUCRBIXXID-UHFFFAOYSA-N
M1339
3,3,3-Trifluoro-2-methoxy-2-phenylpropanoic anhydride
DTXSID60659932
(+)-α-Methoxy-α-(trifluoromethyl)phenylacetic Anhydride
(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ANHYDRIDE

Customs Code

2915240000

FAQ

What are the physical and chemical properties of (+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Anhydride (CAS: 85541-57-7)?

The compound is an anhydride with a crystalline form. Its molecular weight is approximately 295.25 g/mol. It is poorly soluble in water but soluble in organic solvents like dichloromethane and acetonitrile. Chemically, it is reactive, particularly in esterification and amidation reactions. It is stable under normal conditions but requires handling with care due to its reactivity.

How is (+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Anhydride (CAS: 85541-57-7) typically synthesized?

This compound is typically synthesized through the condensation of alpha-methoxy-alpha-(trifluoromethyl)phenylacetic acid with an anhydride-forming reagent. Common methods include the use of phosgene or acetic anhydride. The reaction is conducted under anhydrous conditions to prevent hydrolysis. The yield is generally good, with selectivity towards the desired anhydride product.

What industries use (+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Anhydride (CAS: 85541-57-7)?

This compound is used in the pharmaceutical industry for the synthesis of pharmaceutical intermediates. It is also used in the polymer industry for modifying polymer properties. Additionally, it finds application in the sensor and semiconductor industries for specific chemical modifications and derivatizations.

What precautions should be taken when handling (+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Anhydride (CAS: 85541-57-7)?

When handling this compound, use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a fume hood to avoid inhalation or skin contact. Spills should be handled with care using absorbent materials, and the area should be flushed with water. Refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.