Compound Q&A

How is (+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Anhydride (CAS: 85541-57-7) typically synthesized?

Answer

(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Anhydride
This compound is typically synthesized through the condensation of alpha-methoxy-alpha-(trifluoromethyl)phenylacetic acid with an anhydride-forming reagent. Common methods include the use of phosgene or acetic anhydride. The reaction is conducted under anhydrous conditions to prevent hydrolysis. The yield is generally good, with selectivity towards the desired anhydride product.

About

CAS No 85541-57-7
English Name (+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Anhydride
Molecular Formula C20H16F6O5
Molecular Weight 450.331 g/mol
SMILES COC(C1=CC=CC=C1)(C(=O)OC(=O)C(C2=CC=CC=C2)(C(F)(F)F)OC)C(F)(F)F
InChIKey AATFPUCRBIXXID-UHFFFAOYSA-N
Last Updated: 2026-04-02 10:24

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