1-(3-Nitrophenyl)ethanamine(CAS: 90271-37-7)

1-(3-Nitrophenyl)ethanamine is a colorless to white crystalline solid with a molecular weight of approximately 177.13 g/mol. It has a pKa of about 9.2 and is slightly soluble in water. The compound is reactive towards nucleophiles and can undergo substitution reactions. It is highly sensitive to light and air oxidation.

1-(3-Nitrophenyl)ethanamine is commonly synthesized through a condensation reaction between 3-nitrophenol and ethylamine. The reaction is typically carried out in the presence of a catalyst like sodium acetate to enhance the yield and selectivity. The final product is usually purified by recrystallization from an appropriate solvent.

1-(3-Nitrophenyl)ethanamine finds applications in the pharmaceutical industry for the synthesis of various drug intermediates. It is also used in the polymer industry for the development of certain types of resins and coatings. Additionally, it has applications in sensors and as a precursor in the electronics industry for semiconductor materials.

When handling 1-(3-Nitrophenyl)ethanamine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood due to its volatility. Spills should be cleaned up using appropriate methods, and exposure to the compound should be minimized. Safety data sheets (SDS) should be referenced for detailed information on handling and storage.