N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-serine

Basic Information

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CAS Number

71989-33-8

Molecular Formula

C22H25NO5

Molecular Weight

383.44 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

127-131 ºC

Boiling Point

510.36°C (rough estimate)

Density

1.217

Flash Point

303.7 °C

Refractive Index

1.575

Specific Rotation

25 º (c=1,EtOAc 24 ºC)

SMILES

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CC(C)(C)OCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

InChI

InChI=1S/C22H25NO5/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/t19-/m0/s1

InChIKey

REITVGIIZHFVGU-IBGZPJMESA-N

LogP

3.7934000000000028

Topological Polar Surface Area

84.86 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

536

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Fmoc-Ser(tBu)-OH, >=98.0% (HPLC)
ZK6MDK63M3
O-tert-Butyl-N-(9-fluorenylmethoxycarbonyl)serine
Fmoc-O-tert.butyl-L-serine
Fmoc-L-Ser(tBu)-OH
71989-33-8
Fmoc-O-(tert-butyl)-L-serine
DS-13762
M03382
N-(9-Fluorenylmethoxycarbonyl)-O-tert-butylserine
Fmoc-Ser(tBu)-OH
Fmoc-L-Ser(OtBu)-OH
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]propanoic acid
Fmoc-Ser(t-Bu)-OH
N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyl)-L-serine
(2S)-3-(tert-Butoxy)-2-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)propanoic acid
AKOS015924250
MFCD00037127
Fmoc-L-Ser(OtBu)OH
S-71989-33-8
N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-serine
DTXSID601231254
L-Serine, O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
N-Fmoc-O-tert-Butyl-L-serine
AKOS015895406
N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-serine
J-300241
Fmoc-Ser(tBu)
Fmoc-O-tert-butyl-L-serine
(2S)-3-(tert-butoxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-tert-butoxypropanoic acid

MDL Number

MFCD00037127

Customs Code

2924299090

FAQ

What is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-serine (CAS: 71989-33-8)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-serine is a protected amino acid derivative with the CAS number 71989-33-8. It features a fluorenylmethoxy carbonyl (Fmoc) group and a tert-butyl (t-Bu) protecting group on the serine molecule. This compound is commonly used in peptide synthesis as a protected form of L-serine, offering stability and controlled deprotection under specific conditions.

What are the main uses of N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-serine (CAS: 71989-33-8)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-serine (CAS: 71989-33-8) is primarily used in pharmaceutical research and peptide synthesis. Its Fmoc protecting group makes it suitable for solid-phase peptide synthesis, while the tert-butyl group enhances its stability. It is also used in the development of bioactive molecules and drug candidates due to its reactivity and structural versatility.

Is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-serine (CAS: 71989-33-8) safe?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-serine (CAS: 71989-33-8) is generally considered safe when handled properly. It is a synthetic compound and should be treated with standard chemical safety precautions. Protective gloves and goggles are recommended during handling, and it should be stored in a well-ventilated area. Safety data sheets (SDS) should be consulted for detailed handling and disposal guidelines.

How should N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-serine (CAS: 71989-33-8) be stored?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-methyl-2-propanyl)-L-serine (CAS: 71989-33-8) should be stored in a cool, dry, and dark place to maintain its stability. It is best kept in a sealed container at a temperature below 25°C and away from moisture and light. Proper storage helps prevent decomposition and ensures the compound remains suitable for use in chemical and pharmaceutical applications.