2,2,3,3-Tetrafluoropropyl 4-methylbenzenesulfonate(CAS: 786-31-2)

2,2,3,3-Tetrafluoropropyl 4-methylbenzenesulfonate is a crystalline solid with a molecular weight of approximately 338.13 g/mol. It has limited water solubility and is soluble in polar organic solvents such as dimethylformamide (DMF) and dimethylsulfoxide (DMSO). This compound exhibits low reactivity under normal conditions but can undergo substitution reactions under certain conditions, making it useful in organic synthesis. Its physical properties include a melting point of around 55-59°C.

2,2,3,3-Tetrafluoropropyl 4-methylbenzenesulfonate is typically synthesized through the sulfonation of 4-methylbenzenesulfonic acid with 2,2,3,3-tetrafluoropropyl bromide. This process usually requires the use of a Lewis acid catalyst such as aluminum chloride to promote the electrophilic aromatic substitution. The yield of the reaction is moderate, around 60-70%, and the selectivity is high, ensuring the formation of the desired product.

2,2,3,3-Tetrafluoropropyl 4-methylbenzenesulfonate is used in various industries, particularly in the pharmaceutical and polymer industries. It serves as a sulfonating agent in the synthesis of pharmaceuticals and acts as a functional group in the development of advanced polymers with specific properties. Additionally, it finds applications in the production of sensors and semiconductors where its chemical stability and reactivity are advantageous.

When handling 2,2,3,3-Tetrafluoropropyl 4-methylbenzenesulfonate (CAS: 786-31-2), it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or under a fume hood due to its potential volatility. Spills should be cleaned up using appropriate absorbent materials and the area should be properly ventilated. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.