N-[4-(Trifluoromethoxy)phenyl]acetamide

Basic Information

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CAS Number

1737-06-0

Molecular Formula

C9H8F3NO2

Molecular Weight

219.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

115-117°C

SMILES

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CC(=O)NC1=CC=C(C=C1)OC(F)(F)F

InChI

InChI=1S/C9H8F3NO2/c1-6(14)13-7-2-4-8(5-3-7)15-9(10,11)12/h2-5H,1H3,(H,13,14)

InChIKey

QQRLAETWHFRNQH-UHFFFAOYSA-N

LogP

2.5436000000000005

Topological Polar Surface Area

38.33 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

222

Safety Information

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Hazard Statement

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

Maybridge1_000125
4-(Trifluoromethoxy)acetanilide
MixCom1_000235
n-[4-(trifluoromethoxy)phenyl]acetamide
FT-0616868
N-(4-(Trifluoromethoxy)phenyl)acetamide
n1-[4-(trifluoromethoxy)phenyl]acetamide
A811555
TD1036
4'-(Trifluoromethoxy)acetanilide
FS-1139
Acetamide, N-[4-(trifluoromethoxy)phenyl]-
MFCD00075293
Z30533876
alpha,alpha,alpha-Trifluoro-p-acetanisidide
CS-W014768
1737-06-0
p-Acetanisidide, alpha,alpha,alpha-trifluoro-
Acetamide,N-[4-(trifluoromethoxy)phenyl]-
AKOS005257681
DTXSID20169643
SCHEMBL9070653
4'-(TRIFLUOROMETHOXY)ACETANILIDE
N1-[4-(Trifluoromethoxy)phenyl]acetamide
4′-(Trifluoromethoxy)acetanilide
N-[4-(trifluoromethoxy)phenyl]acetamide
4-(TRIFLUOROMETHOXY)ACETANILIDE
4'-(Trifluoromethoxy)acetanilide97%
4'-(Trifluoromethoxy)acetanilide 97%
N-(4-(trifluoromethoxy)phenyl)acetamide

MDL Number

MFCD00075293

Customs Code

2924299090

FAQ

What are the physical and chemical properties of N-[4-(Trifluoromethoxy)phenyl]acetamide (CAS: 1737-06-0)?

N-[4-(Trifluoromethoxy)phenyl]acetamide (CAS: 1737-06-0) is a white to off-white crystalline solid with a molecular weight of approximately 264.14 g/mol. It is slightly soluble in water but more soluble in organic solvents like methanol and acetone. This compound is relatively stable under normal conditions but can react with strong bases or acids. It is used in various applications due to its unique chemical structure.

How is N-[4-(Trifluoromethoxy)phenyl]acetamide (CAS: 1737-06-0) typically synthesized?

N-[4-(Trifluoromethoxy)phenyl]acetamide (CAS: 1737-06-0) is synthesized by reacting 4-(trifluoromethoxy)phenyl isocyanate with acetic acid in the presence of a base such as triethylamine. The process involves careful control of the reaction conditions to ensure high yield and selectivity. The use of a fume hood is recommended due to the potentially toxic nature of the reactants and products.

What industries use N-[4-(Trifluoromethoxy)phenyl]acetamide (CAS: 1737-06-0)?

N-[4-(Trifluoromethoxy)phenyl]acetamide (CAS: 1737-06-0) is used in the pharmaceutical industry for the synthesis of certain drugs due to its unique chemical structure. It also finds applications in the polymer industry as a modifier or additive. Additionally, it is used in the semiconductor and sensor industries for specific chemical functionalization purposes.

What precautions should be taken when handling N-[4-(Trifluoromethoxy)phenyl]acetamide (CAS: 1737-06-0)?

When handling N-[4-(Trifluoromethoxy)phenyl]acetamide (CAS: 1737-06-0), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood due to its potential to release toxic fumes. Spills should be cleaned up immediately with appropriate absorbents, and the area should be properly decontaminated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.