4-Aminobenzotrifluoride hydrochloride(CAS: 90774-69-9)

4-Aminobenzotrifluoride hydrochloride (CAS: 90774-69-9) is a crystalline solid with a molecular weight of approximately 289.91 g/mol. It is slightly soluble in water and highly soluble in organic solvents like DMSO and DMF. This compound is known for its high reactivity, particularly in nucleophilic aromatic substitution reactions.

4-Aminobenzotrifluoride hydrochloride is commonly synthesized through the reaction of 4-bromobenzotrifluoride with an excess of sodium azide followed by acid workup to form the hydrochloride salt. The process involves the formation of azide intermediate and subsequent displacement of bromine by amines to produce the final product.

4-Aminobenzotrifluoride hydrochloride (CAS: 90774-69-9) is primarily used in the pharmaceutical industry for the synthesis of various drug candidates. It is also utilized in the semiconductor industry for the preparation of organic electronic materials. Its reactivity makes it valuable in both academic and industrial research settings.

When handling 4-Aminobenzotrifluoride hydrochloride (CAS: 90774-69-9), ensure the use of appropriate personal protective equipment (PPE) including gloves, safety goggles, and lab coat. This compound should be stored in a cool, dry location away from direct sunlight and flammable materials. Always work in a fume hood to minimize inhalation risks. Refer to the safety data sheet (SDS) for detailed safety information.