3-Iodo-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile(CAS: 956485-59-9)

3-Iodo-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile is a crystalline solid with a molecular weight of approximately 275.01 g/mol. It has low solubility in water but is more soluble in organic solvents like dimethyl sulfoxide (DMSO) and acetonitrile. Chemically, it is relatively stable but reactive towards nucleophiles and reducing agents.

3-Iodo-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile is usually synthesized via the reaction of 1H-pyrrolo[2,3-b]pyridine-4-carbonitrile with iodine in the presence of a Lewis acid catalyst, such as aluminum chloride (AlCl₃). The yield is typically around 70-80%, with good regioselectivity.

3-Iodo-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile is primarily used in pharmaceuticals for its potential as a drug candidate. It also finds use in the synthesis of other organic compounds and as a reagent in academic research, particularly in the field of organometallic chemistry and medicinal chemistry.

When handling 3-Iodo-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile, use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store it in a fume hood to avoid inhalation. In case of a spill, use appropriate containment and clean up procedures as outlined in the Safety Data Sheet (SDS).