(2R)-2-(3-Bromophenyl)pyrrolidine hydrochloride (1:1)(CAS: 1391550-13-2)

(2R)-2-(3-Bromophenyl)pyrrolidine hydrochloride is a crystalline compound with a molecular weight of approximately 294.07 g/mol. It is sparingly soluble in water but soluble in organic solvents like methanol and ethanol. This compound has limited reactivity under normal conditions, but it can undergo substitution reactions under appropriate conditions. Its hydrochloride salt form is commonly used due to its stability and solubility characteristics.

(2R)-2-(3-Bromophenyl)pyrrolidine hydrochloride is typically synthesized through the reaction of 3-bromophenylboronic acid with pyrrolidine in the presence of a palladium catalyst and a base. The reaction conditions, such as the choice of catalyst and base, can significantly affect the yield and selectivity. This method is commonly used in the organic synthesis industry to produce this compound with good efficiency.

(2R)-2-(3-Bromophenyl)pyrrolidine hydrochloride is primarily used in the pharmaceutical industry as an intermediate for the synthesis of drugs. It is also utilized in the development of materials for sensors and semiconductors, due to its unique chemical structure and reactivity. Its use in polymer chemistry is also explored for its potential applications in functional polymers.

When handling (2R)-2-(3-Bromophenyl)pyrrolidine hydrochloride, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat to protect against skin and eye contact. Work should be conducted in a well-ventilated area, preferably in a fume hood, to minimize inhalation risks. In case of spillage, the area should be immediately flushed with water, and proper disposal procedures should be followed. Always refer to the Safety Data Sheet (SDS) for specific safety information and emergency protocols.