Ethyl 5-(1-piperazinyl)-1-benzofuran-2-carboxylate hydrochloride (1:1)(CAS: 765935-67-9)

Ethyl 5-(1-piperazinyl)-1-benzofuran-2-carboxylate hydrochloride is a crystalline compound with a molecular weight of approximately 387.84 g/mol. It has a m.p. of 155-157°C. The compound is soluble in water and ethanol. It is also reactive towards bases and certain functional groups. The hydrochloride salt form enhances its solubility in aqueous media.

Ethyl 5-(1-piperazinyl)-1-benzofuran-2-carboxylate hydrochloride is typically synthesized via a multi-step process involving the condensation of ethyl benzoate with 1-piperazineethane sulfonic acid, followed by the addition of hydrochloric acid to form the hydrochloride salt. The reaction is conducted under mild conditions to ensure high yield and selectivity.

Ethyl 5-(1-piperazinyl)-1-benzofuran-2-carboxylate hydrochloride is primarily used in the pharmaceutical industry for the development of novel drugs. It can also find applications in the sensors and semiconductors industry due to its chemical properties and functional groups.

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling this compound. It should be stored in a fume hood to minimize inhalation risks. Spills should be immediately cleaned up using appropriate absorbent materials. Safety data sheets (SDS) should be consulted for detailed handling and emergency procedures.