4-(4-Morpholinyl)benzoic acid(CAS: 7470-38-4)

4-(4-Morpholinyl)benzoic acid is a crystalline solid with a molecular weight of approximately 233.29 g/mol. It has a pKa of about 7.9, indicating weak acidity. The compound is slightly soluble in water but more soluble in organic solvents like ethanol and acetonitrile. It is reactive towards bases and can undergo esterification and other acid-base reactions.

4-(4-Morpholinyl)benzoic acid is typically synthesized by the condensation of 4-morpholinoaniline with benzoic anhydride in the presence of a catalyst such as pyridine. The reaction mixture is heated to ensure completion, and the final product is purified by recrystallization from an appropriate solvent to obtain the crystalline form with good yield and selectivity.

4-(4-Morpholinyl)benzoic acid is used in various industries. It serves as a key intermediate in the synthesis of pharmaceuticals, particularly in the production of certain pain relievers and anti-inflammatory drugs. It is also utilized in the preparation of polymers and in the development of sensors and materials for semiconductors.

When handling 4-(4-Morpholinyl)benzoic acid, ensure the use of personal protective equipment such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be contained and cleaned up using appropriate absorbents. Refer to the safety data sheet (SDS) for detailed handling and disposal instructions.