2-methoxy-3,4-dihydro-2H-pyran

Basic Information

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CAS Number

4454-05-1

Molecular Formula

C6H10O2

Molecular Weight

114.14 g/mol

Basic Physical Properties

Boiling Point

127°C

Flash Point

26 ºC

Refractive Index

1.442

SMILES

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COC1CCC=CO1

InChI

InChI=1S/C6H10O2/c1-7-6-4-2-3-5-8-6/h3,5-6H,2,4H2,1H3

InChIKey

XCYWUZHUTJDTGS-UHFFFAOYSA-N

LogP

1.283

Topological Polar Surface Area

18.46 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

88.5

Safety Information

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Hazard Statement

H225 Highly Flammable liquid and vapor
Flammable liquids

H313 May be harmful in contact with skin
Acute toxicity, dermal

H315 Causes skin irritation
Skin corrosion/irritation

H320 Causes eye irritation
Serious eye damage/eye irritation

H371 May cause damage to organs
Specific target organ toxicity, single exposure

H372 Causes damage to organs through prolonged or repeated exposure
Specific target organ toxicity, repeated exposure

Hazard Class

Class 3 Class 3

Synonyms & References

English

W-106189
2H-Pyran, 3,4-dihydro-2-methoxy-
MFCD00006560
F8880-1937
Z995169098
LS-13151
3,4-Dihydro-2-methoxy-2H-pyran, 99%
2-Methoxy-2,3-dihydro-4H-pyran
DTXSID9027570
?3,4-Dihydro-2-methoxy-2H-pyran
3,4-dihydro-2-methoxypyran
DTXCID807570
NSC44974
Tox21_200063
SCHEMBL727275
QF1850DW4W
2,3-Dihydro-2-methoxy(4H)pyran
CHEMBL3181867
Q27894404
EN300-65007
EC 224-698-3
NSC 44974
NCGC00248511-01
4454-05-1
FT-0635304
D1554
2H-Pyran,4-dihydro-2-methoxy-
NCGC00257617-01
2-Methoxy-3,4-dihydro-2H-pyran
NSC-44974
NS00003422

MDL Number

MFCD00006560

Customs Code

2932999099

FAQ

What are the physical and chemical properties of 2-methoxy-3,4-dihydro-2H-pyran (CAS: 4454-05-1)?

2-Methoxy-3,4-dihydro-2H-pyran (CAS: 4454-05-1) is a colorless to slightly yellow liquid with a molecular weight of approximately 130.17 g/mol and a density of 1.04 g/cm³. It has a low melting point of -16°C and a boiling point of 130°C. Soluble in water and organic solvents. It is relatively stable under normal conditions but may undergo ring-opening reactions with strong acids or bases.

How is 2-methoxy-3,4-dihydro-2H-pyran (CAS: 4454-05-1) typically synthesized?

2-Methoxy-3,4-dihydro-2H-pyran is typically synthesized through a Wittig reaction using methyl methoxy phosphonate and prop-2-enal, catalyzed by a Lewis acid like aluminum trichloride. The reaction is carried out in a suitable solvent like dichloromethane at room temperature, yielding a pure product with a high yield of up to 95%.

What industries use 2-methoxy-3,4-dihydro-2H-pyran (CAS: 4454-05-1)?

2-Methoxy-3,4-dihydro-2H-pyran (CAS: 4454-05-1) is used in the pharmaceutical industry for the synthesis of various drugs, in polymer chemistry as a monomer, and in the production of sensors and semiconductors due to its unique structural properties. It acts as a versatile building block in organic synthesis and finds applications in various other fields as well.

What precautions should be taken when handling 2-methoxy-3,4-dihydro-2H-pyran (CAS: 4454-05-1)?

When handling 2-methoxy-3,4-dihydro-2H-pyran (CAS: 4454-05-1), use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhaling vapors. Store the compound in a tightly sealed container away from heat sources and incompatible materials. In case of a spill, use appropriate containment and follow the safety data sheet (SDS) for cleanup instructions.