6-Bromo-2-nitro-3-pyridinol(CAS: 443956-08-9)

6-Bromo-2-nitro-3-pyridinol (CAS: 443956-08-9) is a crystalline solid with a molecular weight of approximately 217.03 g/mol. It is slightly soluble in water and has a pKa of about 6.5. Chemically, it is highly reactive, particularly towards nucleophilic substitution reactions at the bromine substituent and nitro group.

6-Bromo-2-nitro-3-pyridinol (CAS: 443956-08-9) is typically synthesized via the nitration of 6-bromo-3-pyridinol followed by reduction of the nitro group. Common methods include the use of concentrated nitric acid and sulfuric acid as the nitration reagent, and subsequent reduction with sodium borohydride or other mild reducing agents.

6-Bromo-2-nitro-3-pyridinol (CAS: 443956-08-9) finds applications in the pharmaceutical industry, particularly in the synthesis of certain drugs and intermediates. It is also used in the polymer industry for the development of new materials and in the sensor industry for the fabrication of gas-sensitive devices.

When handling 6-Bromo-2-nitro-3-pyridinol (CAS: 443956-08-9), it is crucial to use proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to avoid inhalation. Spills should be handled carefully, and the material safety data sheet (MSDS) should be referenced for detailed emergency procedures.