3-(Trifluoromethyl)isonicotinic acid(CAS: 590371-38-3)

3-(Trifluoromethyl)isonicotinic acid (CAS: 590371-38-3) is a crystalline solid with a molecular weight of approximately 217.08 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and acetone. This compound exhibits moderate acidity and is prone to protonation, making it susceptible to reactions with bases and nucleophiles.

3-(Trifluoromethyl)isonicotinic acid is commonly synthesized by reacting 3-(trifluoromethyl)isonicotinoyl chloride with a base such as sodium hydroxide or potassium hydroxide in an aqueous medium. The reaction is typically conducted at room temperature with good yield and selectivity.

3-(Trifluoromethyl)isonicotinic acid is used in various industries, including pharmaceuticals, where it serves as a precursor for the synthesis of drug molecules. It is also used in the development of sensors and semiconductors due to its unique chemical properties.

When handling 3-(Trifluoromethyl)isonicotinic acid, proper personal protective equipment (PPE) should be worn, including gloves, safety goggles, and a laboratory coat. The compound should be stored in a fume hood to minimize exposure to air and to prevent unwanted reactions. Spills should be cleaned up promptly using appropriate absorbent materials, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for detailed handling instructions.