4-Fluoro-3-methoxyphenylboronic acid(CAS: 854778-31-7)

4-Fluoro-3-methoxyphenylboronic acid is a solid compound with a crystalline form. Its molecular weight is approximately 218.13 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and ethanol. It is reactive towards nucleophiles and can participate in boronate ester formation. It is stable under normal laboratory conditions but should be stored in a cool, dry place away from moisture and oxidizing agents.

4-Fluoro-3-methoxyphenylboronic acid is typically synthesized through a Suzuki-Miyaura cross-coupling reaction. The synthesis involves the reaction of 4-fluoro-3-methoxybenzyl bromide with phenylboronic acid in the presence of a palladium catalyst, such as palladium(II) acetate, and a base like sodium carbonate. The reaction is usually carried out in an organic solvent like toluene or dimethylformamide. The yield is generally high, and the reaction is known for its high regioselectivity and chemoselectivity.

4-Fluoro-3-methoxyphenylboronic acid is used in various industries due to its reactivity and utility in organic synthesis. It is primarily used in the pharmaceutical industry for the preparation of drug intermediates. It is also used in the polymer industry for the synthesis of advanced polymers, in the semiconductor industry for the fabrication of electronic materials, and in the sensor industry for the development of chemical sensors.

When handling 4-Fluoro-3-methoxyphenylboronic acid, it is essential to take appropriate safety precautions. It should be handled in a well-ventilated fume hood to avoid inhalation. Personal protective equipment (PPE) such as gloves, goggles, and lab coats is necessary. Spills should be cleaned up immediately using appropriate absorbents. It is recommended to consult the Safety Data Sheet (SDS) for detailed handling and disposal information. If contact with skin or eyes occurs, immediate washing with copious amounts of water is advised, and medical attention should be sought if necessary.