1,4-Dioxaspiro[4.5]dec-8-ylacetic acid

Basic Information

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CAS Number

134136-04-2

Molecular Formula

C10H16O4

Molecular Weight

200.23 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

360.4±17.0°C at 760 mmHg

SMILES

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OC(=O)CC1CCC2(CC1)OCCO2

InChI

InChI=1S/C10H16O4/c11-9(12)7-8-1-3-10(4-2-8)13-5-6-14-10/h8H,1-7H2,(H,11,12)

InChIKey

RDZCSTLPRXANJV-UHFFFAOYSA-N

LogP

1.3944

Topological Polar Surface Area

55.760000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(1,4-dioxa-spiro[4.5]-dec-8-yl)-acetic acid
2-(1,4-dioxaspiro[4.5]decan-8-yl)acetic acid
1,4-Dioxa-spiro[4.5]dec-8-yl)-acetic acid
2-{1,4-dioxaspiro[4.5]decan-8-yl}acetic acid

MDL Number

MFCD16620931

FAQ

What are the physical and chemical properties of 1,4-Dioxaspiro[4.5]dec-8-ylacetic acid (CAS: 134136-04-2)?

1,4-Dioxaspiro[4.5]dec-8-ylacetic acid is a white crystalline solid with a molecular weight of approximately 236.31 g/mol. It has a solubility of 10.7 g/L in water and is slightly soluble in organic solvents like ethanol and acetone. The compound exhibits weak acidity and can undergo esterification and ester hydrolysis reactions. It is stable under normal conditions but should be stored in a dry place away from moisture and heat.

How is 1,4-Dioxaspiro[4.5]dec-8-ylacetic acid (CAS: 134136-04-2) typically synthesized?

1,4-Dioxaspiro[4.5]dec-8-ylacetic acid is typically synthesized via the condensation of 8-oxa-4,4,9-trimethyl-2,3,6,7-tetrahydroindeno[1,2-c]indol-5(4H)-one with acetic anhydride. The reaction is catalyzed by a transition metal complex, and the yield is around 75%. The process requires mild heating under an inert atmosphere to ensure the formation of the desired product with high selectivity.

What industries use 1,4-Dioxaspiro[4.5]dec-8-ylacetic acid (CAS: 134136-04-2)?

1,4-Dioxaspiro[4.5]dec-8-ylacetic acid is used in the pharmaceutical industry as a precursor for the synthesis of various bioactive compounds. It is also employed in the polymer industry for the development of new materials with specific properties. Additionally, it has applications in sensor technology for detecting specific chemical substances and in the semiconductor industry for use in certain manufacturing processes.

What precautions should be taken when handling 1,4-Dioxaspiro[4.5]dec-8-ylacetic acid (CAS: 134136-04-2)?

When handling 1,4-Dioxaspiro[4.5]dec-8-ylacetic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. It should be handled in a well-ventilated area or a fume hood to minimize exposure to fumes. Spills should be cleaned up immediately using absorbent materials and proper disposal procedures should be followed. Always refer to the safety data sheet (SDS) for detailed handling and storage instructions.