How is 4-Fluoro-3-methoxyphenylboronic acid (CAS: 854778-31-7) typically synthesized?

4-Fluoro-3-methoxyphenylboronic acid is typically synthesized through a Suzuki-Miyaura cross-coupling reaction. The synthesis involves the reaction of 4-fluoro-3-methoxybenzyl bromide with phenylboronic acid in the presence of a palladium catalyst, such as palladium(II) acetate, and a base like sodium carbonate. The reaction is usually carried out in an organic solvent like toluene or dimethylformamide. The yield is generally high, and the reaction is known for its high regioselectivity and chemoselectivity.