4-Methyl-3-nitro-2-pyridinamine(CAS: 6635-86-5)

4-Methyl-3-nitro-2-pyridinamine is a crystalline solid with a molecular weight of approximately 192.13 g/mol. It has a solubility of about 10 mg/mL in water and is sparingly soluble in common organic solvents. This compound is known to be moderately reactive, particularly towards nucleophiles and reducing agents, making it useful in various organic reactions.

4-Methyl-3-nitro-2-pyridinamine is typically synthesized via an intermediate nitration of 4-methyl-2-pyridamine followed by reduction of the nitro group. Commonly, this process involves the use of nitric acid and sulfuric acid as the nitration reagents, followed by hydrogenation to reduce the nitro group to an amine. The overall yield is around 85-90%.

4-Methyl-3-nitro-2-pyridinamine is used in the pharmaceutical industry for the synthesis of certain drug intermediates. It is also employed in the sensor technology sector for its ability to act as a sensing material. Additionally, it has applications in the semiconductor industry due to its unique electronic properties, and in the polymer industry for its potential as a precursor or additive.

When handling 4-Methyl-3-nitro-2-pyridinamine, it is crucial to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents, and the material should be disposed of according to local hazardous waste regulations. Always refer to the Safety Data Sheet (SDS) for detailed information and guidelines.