Abemaciclib Impurity 6

Basic Information

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CAS Number

67567-26-4

Molecular Formula

C6H4BrF2N

Molecular Weight

208 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

63-65 °C

Boiling Point

188.2°C at 760 mmHg

Flash Point

67.6℃

SMILES

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C1=C(C=C(C(=C1F)N)F)Br

InChI

InChI=1S/C6H4BrF2N/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,10H2

InChIKey

BFQSQUAVMNHOEF-UHFFFAOYSA-N

LogP

2.3095

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

110

Safety Information

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GHS Hazard Pictograms

H302

H312

H315

H319

H332

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H312 Harmful in contact with skin
Acute toxicity, dermal

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

InChI=1/C6H4BrF2N/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,10H
MFCD00013389
4-BROMO-2,6-DIFLUORO-PHENYLAMINE
DTXSID60346178
(4-bromo-2,6-difluorophenyl)amine
AC-3648
EN300-83060
Q-200442
SCHEMBL58096
4-Bromo-2,6-difluoroaniline, 98%
B3220
AM20060330
2,6-Difluoro-4-bromoaniline
Z1238548705
MB00220
AR-527/43467620
AKOS005064015
4-Bromo-2,6-difluoro aniline
BCP19526
67567-26-4
4-Bromo-2,6-difluoroaniline
4-bromo-2,6-difluoro-aniline
BDBM626216
CS-M3537
CHEMBL4957737
BENZENAMINE, 4-BROMO-2,6-DIFLUORO-
4-Bromo-2,6-difluorobenzenamine
4-bromo-2,6-difluorophenylamine
2,6-difluoro-4-bromo aniline
AS-8191
FT-0612070

MDL Number

MFCD00013389

Customs Code

2921420090

FAQ

What is Abemaciclib Impurity 6 (CAS: 67567-26-4)?

Abemaciclib Impurity 6, with the CAS number 67567-26-4, is a chemical compound that arises as an impurity during the synthesis of abemaciclib. It is typically identified through analytical methods such as HPLC and has a molecular formula of C19H20N2O2. This compound is known for its structural similarity to abemaciclib and is often studied for its potential impact on drug purity and efficacy.

What are the main uses of Abemaciclib Impurity 6 (CAS: 67567-26-4)?

Abemaciclib Impurity 6 is primarily used in pharmaceutical research to identify and quantify impurities in abemaciclib, a CDK4/6 inhibitor used in cancer treatment. It also serves as a reference standard for quality control and analytical testing in drug development. Its applications include ensuring the safety and consistency of abemaciclib in clinical and industrial settings.

Is Abemaciclib Impurity 6 (CAS: 67567-26-4) safe?

Abemaciclib Impurity 6 is generally considered safe when handled according to standard laboratory practices. However, as with any chemical compound, it should be treated with care. Safety data suggests that it has low toxicity, but proper protective measures such as gloves and ventilation are recommended during handling to ensure compliance with safety standards and minimize exposure risks.

How should Abemaciclib Impurity 6 (CAS: 67567-26-4) be stored?

Abemaciclib Impurity 6 should be stored in a cool, dry, and dark place, ideally at 2-8°C. It is recommended to keep it in a sealed container to prevent moisture and air exposure. Maintaining stable storage conditions is crucial to preserve its chemical integrity and ensure accurate analytical results over time.