2,4,7-Trichloropyrido[2,3-d]pyrimidine(CAS: 938443-20-0)

2,4,7-Trichloropyrido[2,3-d]pyrimidine is a solid with a crystalline form. Its molecular weight is approximately 292.02 g/mol. This compound has low water solubility but is soluble in organic solvents like ethanol and acetone. It is moderately reactive towards nucleophiles. It has a melting point of around 230-232°C and a boiling point of 405-406°C under reduced pressure.

2,4,7-Trichloropyrido[2,3-d]pyrimidine is typically synthesized through the condensation of 2,4,7-trichloropyridine with an appropriate aldehyde in the presence of a suitable catalyst such as p-toluenesulfonic acid. The reaction proceeds with good yield and selectivity, and the product can be purified by recrystallization from ethanol.

2,4,7-Trichloropyrido[2,3-d]pyrimidine finds applications in the pharmaceutical industry for the synthesis of certain drugs. It is also used in the chemical industry for the production of dyes and pigments. Additionally, it has potential applications in the development of sensors and materials science.

When handling 2,4,7-Trichloropyrido[2,3-d]pyrimidine, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work must be conducted in a well-ventilated area or a fume hood. Spills should be handled with caution, using appropriate containment measures and materials. Always consult the Material Safety Data Sheet (MSDS/SDS) for detailed safety information and emergency procedures.