(2-Fluoro-5-nitrophenyl)boronic acid(CAS: 819849-20-2)

(2-Fluoro-5-nitrophenyl)boronic acid is a white or off-white crystalline solid with a molecular weight of approximately 288.06 g/mol. It is slightly soluble in water and ethanol. This compound is reactive towards nucleophiles and can undergo boronate ester formation. It is stable under normal conditions but should be handled with care to prevent decomposition.

(2-Fluoro-5-nitrophenyl)boronic acid is typically synthesized through the reaction of 2-fluoro-5-nitrophenol with boron tribromide in anhydrous dichloromethane. This method provides a high yield and good selectivity. Other synthetic routes include the use of other boron sources like boronate esters or boronates under various conditions.

(2-Fluoro-5-nitrophenyl)boronic acid is used in the pharmaceutical industry for the synthesis of drug precursors. It also finds applications in the polymer industry, particularly in the production of functional polymers. Additionally, it is used in the electronics industry for the development of sensors and semiconductors.

When handling (2-Fluoro-5-nitrophenyl)boronic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves and safety goggles. This compound should be handled in a fume hood to minimize exposure. In case of a spill, it should be cleaned up using appropriate protective measures. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and follow all laboratory safety guidelines.