4-(2,4-Difluorophenyl)-4-oxobutanoic acid(CAS: 110931-77-6)

4-(2,4-Difluorophenyl)-4-oxobutanoic acid is a white crystalline solid with a molecular weight of approximately 215.07 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetonitrile. The compound is relatively stable under normal conditions but can react with strong bases and acids. It is typically used in pharmaceutical applications and has a melting point of around 165-167°C.

4-(2,4-Difluorophenyl)-4-oxobutanoic acid is commonly synthesized via a multi-step process involving the protection of an alcohol, followed by a Sonogashira coupling reaction, and subsequent deprotection. This method provides good yield and selectivity, with the use of palladium(II) acetate as a catalyst and triphenylphosphine as a ligand.

4-(2,4-Difluorophenyl)-4-oxobutanoic acid is primarily used in the pharmaceutical industry for the synthesis of various medicinals. It is also utilized in the polymer industry to enhance material properties and in the sensor industry for its reactivity with specific analytes. Additionally, it finds application in semiconductor technology for its potential use in etching solutions.

When handling 4-(2,4-Difluorophenyl)-4-oxobutanoic acid, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up immediately with appropriate absorbents. Always consult the Safety Data Sheet (SDS) for specific handling and disposal instructions. Storage should be at room temperature in a dry, well-ventilated area away from heat sources and incompatible materials.