Compound Q&A
How is 4-(2,4-Difluorophenyl)-4-oxobutanoic acid (CAS: 110931-77-6) typically synthesized?
Answer
4-(2,4-Difluorophenyl)-4-oxobutanoic acid is commonly synthesized via a multi-step process involving the protection of an alcohol, followed by a Sonogashira coupling reaction, and subsequent deprotection. This method provides good yield and selectivity, with the use of palladium(II) acetate as a catalyst and triphenylphosphine as a ligand.
About
CAS No
110931-77-6
English Name
4-(2,4-Difluorophenyl)-4-oxobutanoic acid
Molecular Formula
C10H8F2O3
Molecular Weight
214.17 g/mol
SMILES
C1=CC(=C(C=C1F)F)C(=O)CCC(=O)O
InChIKey
OKYUHFSCTFNDFB-UHFFFAOYSA-N
Last Updated: 2025-10-19 13:36
