Methyl 5-amino-6-iodo-2-pyridinecarboxylate(CAS: 872355-60-7)

Methyl 5-amino-6-iodo-2-pyridinecarboxylate (CAS: 872355-60-7) is a crystalline compound with a molecular weight of approximately 312.03 g/mol. It has a low solubility in water but is soluble in organic solvents such as methanol and DMF. The compound is known for its moderate reactivity, particularly in nucleophilic substitution reactions. It is stable under normal atmospheric conditions but should be handled with care to avoid prolonged exposure to air and moisture.

Methyl 5-amino-6-iodo-2-pyridinecarboxylate (CAS: 872355-60-7) is typically synthesized via nucleophilic substitution of methyl 5-amino-2-pyridinecarboxylate with iodine in the presence of a suitable base such as potassium carbonate. The reaction is carried out in a suitable organic solvent like DMF, and it usually provides a high yield with good selectivity. Catalysts such as copper(II) acetate can also be used to enhance the reaction efficiency.

Methyl 5-amino-6-iodo-2-pyridinecarboxylate (CAS: 872355-60-7) is primarily used in the pharmaceutical industry for the synthesis of various drug intermediates. It is also used in the development of sensors and in the preparation of certain organic materials. Its unique chemical properties make it a valuable reagent in academic research for studying nucleophilic substitution reactions and as a building block for more complex molecules.

Methyl 5-amino-6-iodo-2-pyridinecarboxylate (CAS: 872355-60-7) should be handled in a fume hood due to its potential for generating iodine fumes upon exposure to air. Personal protective equipment (PPE) including gloves, goggles, and a lab coat is essential. In case of a spill, it should be carefully cleaned up using appropriate methods, and the area should be well-ventilated. Safety data sheets (SDS) should be consulted for detailed emergency procedures and storage guidelines.