Folic Acid-d4(CAS: 171777-72-3)

Folic Acid-d4 (CAS: 171777-72-3) is a crystalline derivative of folic acid. It has a molecular weight of approximately 356.22 g/mol. The compound is soluble in water and methanol. It is less reactive than the parent compound, showing limited reactivity under normal conditions. Its physical properties include a melting point around 285°C and a high solubility in organic solvents.

Folic Acid-d4 (CAS: 171777-72-3) is synthesized through the methylation of folic acid with dimethyl sulfate in the presence of a catalyst such as sodium hydroxide. The reaction yields a 95% pure product with high selectivity. The process typically involves dissolving folic acid in a solvent, adding dimethyl sulfate, and then neutralizing with a base to obtain the diastereomerically labeled compound.

Folic Acid-d4 (CAS: 171777-72-3) is primarily used in pharmaceuticals for the synthesis of labeled compounds for research and diagnostic purposes. It is also found in the chemical industry for the development of labeled biomolecules and in the academic and research sectors for studying metabolic pathways.

When handling Folic Acid-d4 (CAS: 171777-72-3), it is essential to use personal protective equipment such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials and the area should be ventilated. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.