3-Amino-3-(4-fluorophenyl)propanoic acid(CAS: 325-89-3)

3-Amino-3-(4-fluorophenyl)propanoic acid is a crystalline solid with a molecular weight of approximately 210.17 g/mol. It has a low solubility in water but is soluble in organic solvents. This compound is moderately reactive, particularly towards nucleophilic substitution reactions and can form stable esters and amides. Its physical properties include a melting point of 165-167°C.

3-Amino-3-(4-fluorophenyl)propanoic acid is commonly synthesized via a multi-step process starting from 4-fluorophenyl acetic acid. The key steps involve fluorophenyl acetic acid reacting with an amino compound in the presence of a suitable catalyst, followed by purification and crystallization. The yield is generally around 80-85%, and the reaction is highly selective.

3-Amino-3-(4-fluorophenyl)propanoic acid is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry as a monomer for developing novel materials. Additionally, it is used in the semiconductor industry as a precursor in the fabrication of semiconductors and sensors.

When handling 3-Amino-3-(4-fluorophenyl)propanoic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be stored in a cool, dry place away from sources of heat and ignition. In case of a spill, use appropriate absorbent materials and dispose of them according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.