(17beta)-3-Oxoandrost-4-ene-17-carboxylic acid(CAS: 302-97-6)

(17beta)-3-Oxoandrost-4-ene-17-carboxylic acid is a crystalline solid with a molecular weight of approximately 304.44 g/mol. It has a low solubility in water but is highly soluble in organic solvents like ethanol and acetone. This compound is not particularly reactive under normal conditions but can undergo hydrolysis in the presence of strong acids or bases. It is important to store it in a dry, cool place away from moisture and heat sources.

(17beta)-3-Oxoandrost-4-ene-17-carboxylic acid can be synthesized through the reduction of androst-4-ene-17-one followed by carboxylation. Commonly, this involves the use of lithium aluminum hydride (LAH) for reduction and then the addition of carbon dioxide in the presence of a base to introduce the carboxylic acid functionality. The reaction is typically carried out under anhydrous conditions to prevent side reactions.

(17beta)-3-Oxoandrost-4-ene-17-carboxylic acid is primarily used in the pharmaceutical industry for the synthesis of progestogens and other steroid hormones. It is also utilized in the sensor technology sector for developing highly sensitive detection systems due to its specific reactivity with certain biological molecules. Additionally, it plays a role in polymer science for the production of certain types of biodegradable polymers.

When handling (17beta)-3-Oxoandrost-4-ene-17-carboxylic acid, it is crucial to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to prevent inhalation of dust or vapors. Spills should be cleaned up immediately using appropriate absorbents and the area should be thoroughly cleaned. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and disposal. Storage should be in a cool, dry place, away from direct sunlight and heat sources.