Betamethasone 21-Acetate

Basic Information

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CAS Number

987-24-6

Molecular Formula

C24H31FO6

Molecular Weight

434.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

Melting Point

200-220 ºC (dec.)

Density

1.0932 (rough estimate)

Refractive Index

1.5980 (estimate)

Specific Rotation

D +140° (chloroform)

SMILES

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CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)O)C)O)F)C

InChI

InChI=1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1

InChIKey

AKUJBENLRBOFTD-RPRRAYFGSA-N

LogP

2.4665

Topological Polar Surface Area

100.9 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

910

Synonyms & References

English

BETAMETHASONE ACETATE (MART.)
Q27114254
B3165
BETAMETHASONE ACETATE (EP IMPURITY)
Betamethasone Acetate, Pharmaceutical Secondary Standard; Certified Reference Material
DTXCID402668
Betamethasone acetate [JAN]
AKUJBENLRBOFTD-QZIXMDIESA-N
Betamethasone acetate, European Pharmacopoeia (EP) Reference Standard
HY-13570B
BETAMETHASONE ACETATE [WHO-DD]
OSURNIA COMPONENT BETAMETHASONE ACETATE
DEXAMETHASONE ACETATE IMPURITY D (EP IMPURITY)
BETAMETHASONE ACETATE
D01402
beta-Methasone acetate
987-24-6
NS00000579
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(acetyloxy)-, (11beta,16beta)-
TI05AO53L7
EINECS 213-578-6
BETAMETHASONE ACETATE [USP-RS]
BETAMETHASONE21-ACETATE
Betamethasone acetate (JAN/USP)
Betamethasone 21-acetate
Betamethasone acetate [USP:JAN]
BETAMETHASONE ACETATE [ORANGE BOOK]
BETAMETHASONE ACETATE COMPONENT OF CELESTONE SOLUSPAN
9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-acetate
betamethasone-acetate
BETAMETHASONE ACETATE [VANDF]

MDL Number

MFCD00867462

FAQ

What are the physical and chemical properties of Betamethasone 21-Acetate (CAS: 987-24-6)?

Betamethasone 21-Acetate is a white to off-white crystalline powder with a molecular weight of approximately 420.55 g/mol. It is poorly soluble in water but soluble in organic solvents such as ethanol and chloroform. Chemically, it is less reactive than other corticosteroids but still exhibits significant anti-inflammatory and immunosuppressive properties.

How is Betamethasone 21-Acetate (CAS: 987-24-6) typically synthesized?

Betamethasone 21-Acetate is typically synthesized via the acetylation of betamethasone, a process that involves the use of acetic anhydride and a suitable catalyst such as an acid like sulfuric acid. The reaction is conducted under mild conditions to ensure high selectivity and yield, with the final product being purified through recrystallization.

What industries use Betamethasone 21-Acetate (CAS: 987-24-6)?

Betamethasone 21-Acetate is primarily used in the pharmaceutical industry for the treatment of various inflammatory and autoimmune conditions. It is also used in the cosmetic industry for its anti-inflammatory properties, although its use in this sector is limited due to potential side effects.

What precautions should be taken when handling Betamethasone 21-Acetate (CAS: 987-24-6)?

When handling Betamethasone 21-Acetate, it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or under a fume hood to minimize exposure. In case of a spill, handle it with care and refer to the Safety Data Sheet (SDS) for detailed instructions on proper disposal and clean-up procedures.