Dexamethasone EP Impurity D (Mometasone Furoate EP Impurity L)

Basic Information

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CAS Number

24916-90-3

Molecular Formula

C22H28O5

Molecular Weight

372.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

Melting Point

230-235°C

Flash Point

198 ºC

Refractive Index

1.61

SMILES

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CC1CC2C3CCC4=CC(=O)C=CC4(C35C(O5)CC2(C1(C(=O)CO)O)C)C

InChI

InChI=1S/C22H28O5/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)22(15)18(27-22)10-20(16,3)21(12,26)17(25)11-23/h6-7,9,12,15-16,18,23,26H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19+,20+,21+,22-/m1/s1

InChIKey

GBDXNHBVYAMODG-QDBZYVRYSA-N

LogP

1.9640999999999997

Topological Polar Surface Area

87.13000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

814

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

EINECS 246-529-2
16-Alpha-Methylepoxide
A-methylpregna-1,4-diene-3,20-dione
9.BETA.,11.BETA.-EPOXY-17,21-DIHYDROXY-16.ALPHA.-METHYLPREGNA-1,4-DIENE-3,20-DIONE
CS-6951
GBDXNHBVYAMODG-QDBZYVRYSA-N
9beta,11beta-epoxy-17alpha,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
AKOS015895224
NS00084484
9 beta ,11 beta -Epoxy-17,21-dihydroxy-16 alpha -methylpregna-1,4-diene-3,20-dione
D97367
Q27258856
(4aS,4bS,5aS,6aS,7R,8R,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a,8-trimethyl-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one
AS-80742
(1S,2S,10S,11S,13R,14R,15S,17S)-14-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyl-18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadeca-3,6-dien-5-one
(9b,11b,16a)-9,11-Epoxy-17,21-dihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
DTXSID10862499
UNII-45O198JS6W
24916-90-3
Dexamethasone Imp. D (EP); 17,21-Dihydroxy-16alpha-methyl-9beta,11beta-epoxypregna-1,4-diene-3,20-dione; 9beta,11beta-Epoxy-17,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione; Dexamethasone 9,11-Epoxide; Dexamethasone Impurity D; Mometasone Furoate Impurity L
Pregna-1,4-diene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-16-methyl-, (9beta,11beta,16alpha)-
HY-N0348
9.BETA.-PREGNA-1,4-DIENE-3,20-DIONE, 9,11.BETA.-EPOXY-17,21-DIHYDROXY-16.ALPHA.-METHYL-
Dexamethasone 9,11-Epoxide
AMY14575
A817550
AC-1550
8DM
SCHEMBL5261130
(1S,2S,10S,11S,13R,14R,15S,17S)-14-HYDROXY-14-(2-HYDROXYACETYL)-2,13,15-TRIMETHYL-18-OXAPENTACYCLO[8.8.0.0(1),(1)?.0(2),?.0(1)(1),(1)?]OCTADECA-3,6-DIEN-5-ONE
(1S,2S,10S,11S,13R,14R,15S,17R)-14-Hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyl-18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadeca-3,6-dien-5-one

MDL Number

MFCD07782140

Customs Code

2937290090

FAQ

What is Dexamethasone EP Impurity D (CAS: 24916-90-3)?

Dexamethasone EP Impurity D, with the CAS number 24916-90-3, is a trace impurity commonly found in the synthesis of dexamethasone, a corticosteroid medication. It is chemically related to dexamethasone and may have similar properties, though its specific structure and function are less well-defined. This compound is typically identified during quality control processes in pharmaceutical manufacturing.

What are the main uses of Dexamethasone EP Impurity D (CAS: 24916-90-3)?

Dexamethasone EP Impurity D is primarily used in the analysis and quality control of dexamethasone and related corticosteroids in pharmaceutical settings. It may also be relevant in research for studying impurity profiles and their impact on drug purity. As an impurity, it is not used therapeutically but is important for ensuring the safety and efficacy of final drug products.

Is Dexamethasone EP Impurity D (CAS: 24916-90-3) safe?

Dexamethasone EP Impurity D is generally considered safe when present in trace amounts as an impurity in pharmaceutical products. However, its safety profile is not well-documented, and precautions should be taken during handling to minimize exposure. Proper safety standards and protocols are essential in its use and analysis to ensure compliance with regulatory requirements.

How should Dexamethasone EP Impurity D (CAS: 24916-90-3) be stored?

Dexamethasone EP Impurity D should be stored in a cool, dry place away from light. It is typically kept in a sealed container at a temperature range of 15-25°C. Maintaining controlled humidity and light exposure is crucial to preserve its stability and prevent degradation during storage.