Deflazacort | CAS No. 14484-47-0

Deflazacort

Basic Information

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CAS Number

14484-47-0

Molecular Formula

C25H31NO6

Molecular Weight

441.52 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

256.0 to 260.0 deg-C

Boiling Point

544.2°C at 760 mmHg

Solubility

DMSO: ≥20mg/mL

Specific Rotation

+62.3° (c=0.5, Chloroform)

SMILES

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CC1=NC2(C(O1)CC3C2(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)C(=O)COC(=O)C

InChI

InChI=1S/C25H31NO6/c1-13-26-25(20(30)12-31-14(2)27)21(32-13)10-18-17-6-5-15-9-16(28)7-8-23(15,3)22(17)19(29)11-24(18,25)4/h7-9,17-19,21-22,29H,5-6,10-12H2,1-4H3/t17-,18-,19-,21+,22+,23-,24-,25+/m0/s1

InChIKey

FBHSPRKOSMHSIF-GRMWVWQJSA-N

LogP

2.5632

Topological Polar Surface Area

102.26 Å²

Hydrogen Bond Donor/Acceptor

1 / 7

Complexity

996

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1 Class 6.1

Toxicity

LD50 orally in mice: 5200 mg/kg (Schiatti)

Synonyms & References

English

3-AMINO-3-(4-CHLORO-3-NITRO-PHENYL)-PROPIONICACID
KS-1158
[2-[(1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-6,9,13-trimethyl-16-oxo-5-oxa-7-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-6,14,17-trien-8-yl]-2-oxoethyl] acetate
2-[(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-6b-yl]-2-oxoethyl acetate
DEFLAZACORT (MART.)
CHEMBL1201891
NCGC00255189-01
NCGC00263521-01
Cortax
s1888
Oxazacort
DEFLAZACORT [ORANGE BOOK]
BCP08474
Deflazacortum [INN-Latin]
11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate
CAS-14484-47-0
AKOS015895199
5'H-PREGNA-1,4-DIENO(17,16-D)OXAZOLE-3,20-DIONE, 21-(ACETYLOXY)-11-HYDROXY-2'-METHYL-, (11.BETA.,16.BETA.)-
L-5458
EINECS 238-483-7
Deflazacort (Calcort)
Azacort
Deflazacortum
Deflan
(11beta,16beta)-21-(Acetyloxy)-11-hydroxy-2'-methyl-5'H-pregna-1,4-dieno(17,16-d)oxazole-3,20-dione
(11beta,16beta)-21-(acetyloxy)-11-hydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione
Q-101371
DEFLAZACORT [MI]
Deflazacort [USAN:INN:BAN]
2-[(1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-6,9,13-trimethyl-16-oxo-5-oxa-7-azapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-6,14,17-trien-8-yl]-2-oxoethyl acetate
Q779118

MDL Number

MFCD00866106

Customs Code

2937290090

FAQ

What is Deflazacort (CAS: 14484-47-0)?

Deflazacort is a synthetic corticosteroid with the chemical formula C23H30F2O5. It is characterized by its anti-inflammatory and immunosuppressive properties, making it useful in medical treatments. Deflazacort is a derivative of dexamethasone and is commonly used in pharmaceutical applications for managing conditions like asthma, allergies, and autoimmune disorders.

What are the main uses of Deflazacort (CAS: 14484-47-0)?

Deflazacort is primarily used in medicine as an anti-inflammatory and immunosuppressive agent. It is prescribed for treating respiratory conditions, skin diseases, and inflammatory disorders. Additionally, it may be used in research to study corticosteroid mechanisms and in veterinary medicine for specific therapeutic purposes.

Is Deflazacort (CAS: 14484-47-0) safe?

Deflazacort is considered safe when used as directed, but it can have side effects such as adrenal suppression, weight gain, and increased susceptibility to infections. Proper handling and adherence to safety guidelines are essential, especially in medical and industrial settings. It is classified as a controlled substance in some regions due to its potential for misuse.

How should Deflazacort (CAS: 14484-47-0) be stored?

Deflazacort should be stored in a cool, dry place away from direct light. It is typically kept in a sealed container at temperatures between 15°C to 25°C. Maintaining proper humidity levels and ensuring storage conditions are stable are crucial to preserving its potency and effectiveness over time.