4-Cyclopropoxyphenylboronic acid(CAS: 871829-90-2)

4-Cyclopropoxyphenylboronic acid is a white or off-white crystalline solid with a molecular weight of approximately 262.3 g/mol. It has good solubility in organic solvents like dichloromethane and poor solubility in water. The compound exhibits electrophilic reactivity towards nucleophiles and can undergo various reactions such as coupling reactions. It is stable under normal conditions but should be stored away from moisture and strong acids.

4-Cyclopropoxyphenylboronic acid can be synthesized via the boronation of 4-hydroxybenzaldehyde with cyclopropanol in the presence of a boronic acid catalyst, such as tetrakis(triphenylphosphine)palladium(0), in the presence of a base like triethylamine. The reaction typically yields a product with a high degree of purity and selectivity, with a yield of around 70-80%.

4-Cyclopropoxyphenylboronic acid is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry as a precursor for the production of various polymers and in the sensor industry for the fabrication of chemical and biological sensors. Additionally, it is used in the semiconductor industry for the production of specific materials.

When handling 4-Cyclopropoxyphenylboronic acid (CAS: 871829-90-2), appropriate personal protective equipment (PPE) should be worn, including gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials, and the area should be thoroughly rinsed with water. Refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.