1-isopropyl-3,5-dimethyl-1H-pyrazole-4-carboxylic acid
CAS Number:
1007542-01-9
Molecular Formula:
C9H14N2O2
Pore-interface engineering improves doxorubicin loading to triazine-based covalent organic framework
Literature Information
Publication Date
2023-12-01
DOI
10.1039/D3MA00673E
Impact Factor
0
Authors
Preeti Rathi, Sumanta Chowdhury, Partha Pratim Das, Anand Kumar Keshri, Anubha Chaudhary, Prem Felix Siril
View Original
Abstract
High drug-loading capacity is the most advantageous property of porous nanocarriers for cancer therapy. Covalent organic frameworks (COFs) are a novel class of porous nanocarriers that have been explored for drug delivery because of their tuneable textural properties and pore-surface functionalization. The primary focus of this study is to determine the dominant factor influencing drug loading in COFs. These results highlight the importance of pore-wall functionalization over the surface area to achieve a high drug-loading capacity and better drug–COF interaction. In vitro biological studies confirmed the biocompatibility of bare COFs and the efficacy of doxorubicin-loaded COF in killing cancer cells. In essence, the findings of this study suggest focussing on drug–COF interactions rather than high crystallinity and surface area for enhanced drug loading.
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