Advances in glycoside and oligosaccharide synthesis

Literature Information

Publication Date 2023-10-13
DOI 10.1039/D3CS00321C
Impact Factor 54.564
Authors

Conor J. Crawford


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Abstract

The structural complexity of glycans poses a serious challenge in the chemical synthesis of glycosides, oligosaccharides and glycoconjugates. Glycan complexity, determined by composition, connectivity, and configuration far exceeds what nature achieves with nucleic acids and proteins. Consequently, glycoside synthesis ranks among the most complex tasks in organic synthesis, despite involving only a simple type of bond-forming reaction. Here, we introduce the fundamental principles of glycoside bond formation and summarize recent advances in glycoside bond formation and oligosaccharide synthesis.

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DOI: 10.1039/C6QO90030E

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Source Journal

Chemical Society Reviews

Chemical Society Reviews
CiteScore: 80.8
Self-citation Rate: 1.2%
Articles per Year: 250

Chem Soc Rev publishes review articles covering important topics at the forefront of the chemical sciences. Reviews should be of the very highest quality and international impact. We particularly encourage international and multidisciplinary collaborations among our authors. Our scope covers the breadth of the chemical sciences, including interdisciplinary topics where the article has a basis in chemistry. Topics include: Analytical chemistry Biomaterials chemistry Bioorganic/medicinal chemistry Catalysis Chemical Biology Coordination Chemistry Crystal Engineering Energy Sustainable chemistry Green chemistry Inorganic chemistry Inorganic materials Main group chemistry Nanoscience Organic chemistry Organic materials Organometallics Physical chemistry Supramolecular chemistry Synthetic methodology Theoretical and computational chemistry

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