Direct construction of chiral quaternary dihydropyranones through highly enantioselective organocatalytic hetero-Diels–Alder reactions of olefinic azlactones
Literature Information
Publication Date
2016-03-03
DOI
10.1039/C6QO00018E
Impact Factor
5.281
Authors
Tai-Ping Gao, Dan Liu, Jun-Bing Lin, Xiu-Qin Hu, Zhu-Yin Wang, Peng-Fei Xu
View Original
Abstract
The first organocatalytic hetero-Diels–Alder reaction of an in situ generated diene with either α-keto esters or β,γ-unsaturated α-keto esters was successfully developed. The densely functionalized dihydropyranones with a highly congested quaternary center were readily obtained in moderate to good yields with excellent enantioselectivities under mild conditions.
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Organic Chemistry Frontiers
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