Synthesis of fused isoquinolines via gold-catalyzed tandem alkyne amination/intramolecular O–H insertion

Literature Information

Publication Date 2016-02-12
DOI 10.1039/C6QO00033A
Impact Factor 5.281
Authors

Yuan Pan, Gui-Wei Chen, Cang-Hai Shen, Weimin He


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Abstract

A novel gold-catalyzed tandem alkyne amination/intramolecular O–H insertion has been developed. A variety of [1,4]oxazino[3,2-c]isoquinolines are readily accessed under mild reaction conditions by utilizing this strategy, thereby providing an efficient and practical route for the construction of synthetically useful fused isoquinolines.

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Organic Chemistry Frontiers

Organic Chemistry Frontiers
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Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

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