Development of 18F-Labeled hydrophilic trans-cyclooctene as a bioorthogonal tool for PET probe construction
Literature Information
Muyun Xu, Xinrui Ma, Jessica E. Pigga, He Zhang, Shuli Wang, Weiling Zhao, Huaifu Deng, Anna M. Wu, Rihe Liu, Zhanhong Wu, Joseph M. Fox, Zibo Li
We report the development of a hydrophilic 18F-labeled a-TCO derivative [18F]3 (log P = 0.28) through a readily available precursor and a single-step radiofluorination reaction (RCY up to 52%). We demonstrated that [18F]3 can be used to construct not only multiple small molecule/peptide-based PET agents, but protein/diabody-based imaging probes in parallel.
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Chemical Communications

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