Biosynthesis of the fungal nonribosomal peptide penilumamide A and biochemical characterization of a pterin-specific adenylation domain
Literature Information
Publication Date
2023-09-06
DOI
10.1039/D3CB00088E
Impact Factor
0
Authors
Stephanie C. Heard, Katharine L. Diehl, Jaclyn M. Winter
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Abstract
We report the characterization of the penilumamide biosynthetic cluster from Aspergillus flavipes CNL-338. In vitro reconstitution experiments demonstrated that three nonribosomal peptide synthetases are required for constructing the tripeptide and studies with dissected adenylation domains allowed for the first biochemical characterization of a domain that selects a pterin-derived building block.
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