A general route to fluorinated 3,3-disubstituted 2-oxindoles via a photoinduced radical cyclization of N-arylacrylamides under catalyst-free conditions
Literature Information
Publication Date
2016-03-03
DOI
10.1039/C6QO00055J
Impact Factor
5.281
Authors
Yuanyuan An, Yuewen Li
View Original
Abstract
A catalyst-free radical cyclization of N-arylacrylamides with fluorinated alkyl iodides or the Togni reagent enabled by photoenergy is presented for the first time. Under ultraviolet irradiation, the generation of fluorinated 3,3-disubstituted 2-oxindoles proceeds smoothly without any metals or photoredox catalysts. The broad reaction scope is demonstrated with good functional group tolerance. During the process, fluorinated alkyl groups can be easily incorporated.
Recommended Journals
Russian Journal of Bioorganic Chemistry
Journal of Saudi Chemical Society
Russian Journal of Coordination Chemistry
Russian Journal of Organic Chemistry
Crystallography Reports
Chemical Communications
Journal of Peptide Science
Russian Journal of General Chemistry
Current Opinion in Solid State & Materials Science
Current Opinion in Colloid & Interface Science
Related Literature
Short peptide based self-assembled nanostructures: implications in drug delivery and tissue engineering
Virander Singh Chauhan
2014-04-23
Review Article
DOI: 10.1039/C4PY00173G
Thiol–ene “click” reactions and recent applications in polymer and materials synthesis: a first update
Andrew B. Lowe
2014-05-01
Review Article
DOI: 10.1039/C4PY00339J
Diels–Alder crosslinked HA/PEG hydrogels with high elasticity and fatigue resistance for cell encapsulation and articular cartilage tissue repair
2014-05-13
Paper
DOI: 10.1039/C4PY00473F
Mesogen-jacketed liquid crystalline polymers with peripheral oligo(ethylene oxide) chains: phase structure and thermoresponsive behavior
Qian Tan, Junqiu Liao, Sheng Chen, Ya Zhu, Hailiang Zhang
2014-05-09
Paper
DOI: 10.1039/C4PY00371C
Statistical terpolymers with thermo-responsive fluorescence response in an ionic liquid: effects of solvatophilicity on LCST phase separation and reversibility
Chi Zhang, Milan Maric
2014-04-16
Paper
DOI: 10.1039/C4PY00300D
Macromolecular covalently cross-linked quaternary ammonium poly(ether ether ketone) with polybenzimidazole for anhydrous high temperature proton exchange membranes
Na Zhang, Chengji Zhao, Wenjia Ma, Shuang Wang, Baolong Wang, Gang Zhang, Xuefeng Li, Hui Na
2014-04-14
Paper
DOI: 10.1039/C4PY00234B
Highly pH-sensitive polyurethane exhibiting shape memory and drug release
Ying Li, Ye Liu, Tao Gong, Lin Wang, Shaobing Zhou
2014-05-02
Paper
DOI: 10.1039/C4PY00474D
Multi-stimuli responsive poly(azodibenzo-18-crown-6-ether)s
S. Wiktorowicz, H. Tenhu, V. Aseyev
2014-04-16
Paper
DOI: 10.1039/C4PY00298A
You might also like
Compound Q&A
What is Ethyl 3-cyclohexylpropanoate (CAS: 10094-36-7)?
Ethyl 3-cyclohexylpropanoate is a clear, colorless to light yellow liquid with a...
10094-36-7Ethyl 3-cyclohexylpr...
Compound Q&A
How should waste containing 2-(Hydroxymethyl)-5-(methoxycarbonyl)-6-methyl-4-(2-nitrophenyl)nicotinic acid (CAS: 34783-31-8) be handled?
Waste containing 2-(Hydroxymethyl)-5-(methoxycarbonyl)-6-methyl-4-(2-nitrophenyl...
34783-31-82-(Hydroxymethyl)-5-...
Compound Q&A
How should waste containing 2,4,6-Tris(pentafluoroethyl)-1,3,5-triazine (CAS: 858-46-8) be handled?
Waste containing 2,4,6-Tris(pentafluoroethyl)-1,3,5-triazine (CAS: 858-46-8) sho...
858-46-82,4,6-Tris(pentafluo...
Compound Q&A
What precautions should be taken when handling Chloroac-nle-oh (CAS: 56787-36-1)?
When handling Chloroac-nle-oh (CAS: 56787-36-1), it is essential to wear appropr...
56787-36-1Chloroac-nle-oh
Compound Q&A
What industries use Ethyl 6-phenylimidazo[2,1-b][1,3]thiazole-3-carboxylate (CAS: 752244-05-6)?
Ethyl 6-phenylimidazo[2,1-b][1,3]thiazole-3-carboxylate is primarily used in the...
752244-05-6Ethyl 6-phenylimidaz...
Compound Q&A
Are there alternatives to alpha-(2-Bromophenyl)benzylamine (CAS: 55095-15-3) in synthesis?
Alternatives to alpha-(2-Bromophenyl)benzylamine (CAS: 55095-15-3) in synthesis ...
55095-15-3alpha-(2-Bromophenyl...
Compound Q&A
How should waste containing 2-Chloro-5-methoxypyridine (CAS: 139585-48-1) be handled?
Waste containing 2-Chloro-5-methoxypyridine (CAS: 139585-48-1) should be managed...
139585-48-12-Chloro-5-methoxypy...
Compound Q&A
What industries use 1-(4-Methoxyphenyl)-2,5-dimethyl-1H-pyrrole (CAS: 5044-27-9)?
1-(4-Methoxyphenyl)-2,5-dimethyl-1H-pyrrole (CAS: 5044-27-9) is used in various ...
5044-27-91-(4-Methoxyphenyl)-...
Compound Q&A
Are there alternatives to 3-Bromo-5-(N-Boc)aminomethylisoxazole (CAS: 903131-45-3) in synthesis?
There are alternative reagents and compounds that can be used in the synthesis o...
903131-45-33-Bromo-5-(N-Boc)ami...
Compound Q&A
What is Tungsten(IV) oxide (CAS: 12036-22-5)?
Tungsten(IV) oxide, also known as tungsten dioxide, is a chemical compound with ...
12036-22-5Tungsten(IV) oxide
Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.