Regiospecific synthesis of distally chlorinated ketones via C–C bond cleavage of cycloalkanols
Literature Information
Publication Date
2015-12-10
DOI
10.1039/C5QO00368G
Impact Factor
5.281
Authors
Xuefeng Fan, Huijun Zhao, Jiajia Yu, Xiaoguang Bao
View Original
Abstract
A variety of distally Csp3-chlorinated ketones are synthesized with good regioselectivities via silver-catalyzed ring opening of cycloalkanols under mild reaction conditions. The reaction uses only routine, inexpensive reagents and can be scaled up to gram quantities. A novel radical-mediated C–C bond cleavage/C–Cl bond formation is proposed.
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Organic Chemistry Frontiers
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