A niclosamide–tobramycin hybrid adjuvant potentiates cefiderocol against P. aeruginosa

Literature Information

Publication Date 2021-07-27
DOI 10.1039/D1MD00206F
Impact Factor 0
Authors

Liam Berry, Marc Brizuela, Gregory Jackson


View Original

Abstract

There is an urgent need for new therapies to overcome antimicrobial resistance (AMR) especially against Gram-negative bacilli (GNB). Multicomponent therapy combining antibiotics with enhancer molecules known as adjuvants is an emerging strategy to combat AMR. We have previously reported tobramycin-based adjuvants which are able to potentiate various antibiotics. In order to expand the repertoire of tobramycin hybrid adjuvants, a new hybrid containing niclosamide, an FDA approved anthelmintic which has recently demonstrated a variety of interesting biological effects, was synthesized. It was found that this conjugate can potentiate several antibiotics against multidrug-resistant GNB, including the recently approved siderophore cephalosporin cefiderocol. 8 μg ml−1 of the niclosamide–tobramycin hybrid in combination therapy against a pandrug-resistant strain of P. aeruginosa was able to lower the cefiderocol MIC 32-fold, from 8 μg ml−1 to 0.25 μg ml−1 in iron-rich media where siderophore uptake is reduced. These results indicate that a niclosamide–tobramycin hybrid adjuvant can serve to potentiate a newly approved antibiotic.

Related Literature

Generation and direct EPR spectroscopic observation of triplet arylphosphinidenes: stabilisation versus internal rearrangements

Eugenii Ya. Misochko, Alexander V. Akimov, Denis V. Korchagin, Yulia S. Ganushevich, Egor A. Melnikov, Vasili A. Miluykov

2020-11-18 Paper

DOI: 10.1039/D0CP05254J

Front cover

Cover

DOI: 10.1039/D0CP90102D

Interaction of water with oligo(ethylene glycol) terminated monolayers: wetting versus hydration

Mustafa Sayin, Alexei Nefedov, Michael Zharnikov

2020-03-27 Paper

DOI: 10.1039/D0CP00906G

Study of the surface species during thermal and plasma-enhanced atomic layer deposition of titanium oxide films using in situ IR-spectroscopy and in vacuo X-ray photoelectron spectroscopy

Elisabeth Levrau, Matthias M. Minjauw, Michiel Van Daele, Rita Vos, Jolien Dendooven, Christophe Detavernier

2020-04-08 Paper

DOI: 10.1039/D0CP00395F

Tuning of ORR activity through the stabilization of the adsorbates by hydrogen bonding with substituent groups

Nagaprasad Reddy Samala, Ilya Grinberg

2020-11-04 Paper

DOI: 10.1039/D0CP04478D

The statistical molecular fragmentation model compared to experimental plasma induced hydrocarbon decays

Stéphane Pasquiers, Nicole Blin-Simiand, Lionel Magne, Nguyen-Thi Van-Oanh, Sébastien Thomas

2020-03-20 Paper

DOI: 10.1039/C9CP06958E

Can glycine betaine denature proteins?

Arusha Acharyya, Dayoung Shin, Thomas Troxler, Feng Gai

2020-03-30 Paper

DOI: 10.1039/D0CP00397B

Metal extraction from a deep eutectic solvent, an insight into activities

Peng Cen, Mikhail S. Tyumentsev, Mark R. St. J. Foreman

2020-04-28 Paper

DOI: 10.1039/C9CP05982B

Ab initio investigation of the formation mechanism of nano-interfaces between 3d-late transition-metals and ZrO2 nanoclusters

Larissa Zibordi-Besse, Lucas G. Verga, Vivianne K. Ocampo-Restrepo, Juarez L. F. Da Silva

2020-03-25 Paper

DOI: 10.1039/D0CP00584C

You might also like

155412-88-71-(3-Aminophenyl)-3-...
Compound Q&A

How should waste containing 1-(D-Ribofuranosyl)-1,4-dihydro-3-pyridinecarboxamide (CAS: 19132-12-8) be handled?

Waste containing 1-(D-Ribofuranosyl)-1,4-dihydro-3-pyridinecarboxamide (CAS: 191...

19132-12-81-(D-Ribofuranosyl)-...
Compound Q&A

What regulatory guidelines apply to 2-Methyl-2-propanyl 3-bromo-3-(hydroxymethyl)-1-azetidinecarboxylate (CAS: 2007919-81-3)?

2-Methyl-2-propanyl 3-bromo-3-(hydroxymethyl)-1-azetidinecarboxylate (CAS: 20079...

2007919-81-32-Methyl-2-propanyl ...
Compound Q&A

What is N-(4-Chloro-2-pyridinyl)acetamide (CAS: 245056-66-0)?

N-(4-Chloro-2-pyridinyl)acetamide (CAS: 245056-66-0) is a chemical compound with...

245056-66-0N-(4-Chloro-2-pyridi...
Compound Q&A

What is 5-Chloro-2-hydroxybenzoic acid (CAS: 321-14-2)?

5-Chloro-2-hydroxybenzoic acid, also known as 5-chlorosalicylic acid, is an arom...

321-14-25-Chloro-2-hydroxybe...
Compound Q&A

What precautions should be taken when handling 1,1-Dichloro-1-fluoroethane (CAS: 1717-00-6)?

When handling 1,1-Dichloro-1-fluoroethane (CAS: 1717-00-6), it is important to u...

1717-00-61,1-Dichloro-1-fluor...
Compound Q&A

What are the physical and chemical properties of Fmoc-(2S,3R)-3-phenylpyrrolidine-2-carboxylic acid (CAS: 281655-32-1)?

Fmoc-(2S,3R)-3-phenylpyrrolidine-2-carboxylic acid is a white crystalline solid ...

281655-32-1Fmoc-(2S,3R)-3-pheny...
Compound Q&A

What are the main uses of 4-Amino-5-bromo-2-pyridinecarboxylic acid (CAS: 1363381-01-4)?

4-Amino-5-bromo-2-pyridinecarboxylic acid is primarily used as a precursor in th...

1363381-01-44-Amino-5-bromo-2-py...
1007881-98-2(S)-tert-butyl 2-((2...
Compound Q&A

What precautions should be taken when handling 8-bromo-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one (CAS: 688363-73-7)?

When handling 8-bromo-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one, use prop...

688363-73-78-bromo-2,2-dimethyl...
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.