Reactive crystallization: a review

Literature Information

Publication Date 2020-11-16
DOI 10.1039/D0RE00272K
Impact Factor 4.239
Authors

Matthew A. McDonald, Hossein Salami, Patrick R. Harris, Colton E. Lagerman, Xiaochuan Yang, Andreas S. Bommarius, Martha A. Grover, Ronald W. Rousseau


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Abstract

Reactive crystallization is not new, but there has been recent growth in its use as a means of improving performance and sustainability of industrial processes. This review examines phenomena and processes in which reaction and crystallization are coupled in the production of a desired chemical species. Coverage includes fundamental phenomena, such as solubility, supersaturation, crystal nucleation and growth, and chemical kinetics. Systems examined are divided into two groups, those best described as undergoing ionic reactions (including neutralizations), which have near instantaneous rates and result in the formation of ionic bonds, and those undergoing covalent reactions in which the key step occurs at measurable rates and results in the formation of covalent bonds. Discussion of the latter category also includes the impact of catalysis. Examples of a variety of reactions and applications are enumerated, and special attention is given to the utility of reactive crystallization in chiral resolution. Integration of reactive crystallization into process design, including both batch and continuous operations, and the development and efficacy of modeling, monitoring and control are reviewed. Finally, a perspective addressing needs to advance the usefulness and applications of reactive crystallization is included.

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Contents

Front/Back Matter

DOI: 10.1039/C0CP90137G

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Source Journal

Reaction Chemistry & Engineering

Reaction Chemistry & Engineering
CiteScore: 0
Self-citation Rate: 8.8%
Articles per Year: 284

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.

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