1-Methyl-2-pyrrolidinone

Basic Information

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CAS Number

872-50-4

Molecular Formula

C5H9NO

Molecular Weight

99.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

−24 °C

Boiling Point

202 °C<br />81-82 °C/10 mmHg

Density

1.028 g/mL at 25 °C

Water Solubility

>=10 g/100 mL at 20 ºC

Solubility

ethanol: miscible0.1ML/mL, clear, colorless (10%, v/v)

Refractive Index

n20/D 1.47(lit.)

Vapor Pressure

0.29 mmHg ( 20 °C)<br />0.99 mmHg ( 40 °C)

SMILES

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CN1CCCC1=O

InChI

InChI=1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

InChIKey

SECXISVLQFMRJM-UHFFFAOYSA-N

LogP

0.23859999999999992

Topological Polar Surface Area

20.310000000000002 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

90.1

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

H360

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

H360 May damage fertility or the unborn child
Reproductive toxicity

Stability

Stable, but decomposes upon exposure to light. Combustible. Incompatible with strong oxidizing agents, strong acids, reducing agents, bases.

Sensitiveness

Hygroscopic

Explosive Limit

1.3-9.5%(V)

Synonyms & References

English

1-Methyl-2-pyrrolidinone
1-methyl-2-pyrrolidone
NMP
N-Methylpyrrolidone
N-Methylbutyrolactam
N-Methyl-2-pyrrolidone
1-Methyl-2-pyrrolidone (Low water content)
1-Methyl-2-pyrrolidinone (NMP)
M-PYROL
1-Methyl-2-pyrrolidi
1-METHYL-2-PYRROLIDONE, EL
1,6-Dihydro-N-methyl-6-oxonicotinamide
1-methyl-2-oxo-pyrrolidine
1-methylpyrrolidin-2-one
N-methyl-2-pyridone-5-carboxamide
n-methyl-2-pyrrolidinone
n-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide
N-methyl-pyrrolidin-2-one
N-methyl-pyrrolidinone
1-Methyl-2-pyrrolidinone (Low water content)
NMP (Low water content)
N-Methyl pyrrolidone
Methylpyrrolidone
N-Methylpyrrolidinone
1-Methylpyrrolidone
1-Methylpyrrolidinone
2-Pyrrolidinone, 1-methyl-
n-methyl-pyrrolidone
1-Methylazacyclopentan-2-one
1-Methyl-5-pyrrolidinone
N-methylpyrrolidin-2-one

MDL Number

MFCD00003193

FAQ

What is 1-Methyl-2-pyrrolidinone (CAS: 872-50-4)?

1-Methyl-2-pyrrolidinone (1-Methylpyrrolidinone, NMP) is a cyclic amide compound with the chemical formula C5H9NO. It is a colorless, viscous liquid with a slightly sweet odor, known for its high polarity and solubility in water and organic solvents. NMP exhibits excellent stability under normal conditions and is widely used as a versatile solvent and reagent in chemical processes. Its molecular structure consists of a pyrrolidone ring with a methyl group attached, giving it unique solvating properties. NMP is commonly found in pharmaceuticals, polymer science, and industrial applications. Due to its reactivity and utility, it is essential to understand its chemical characteristics for safe handling and effective use in various fields.

What are the main uses of 1-Methyl-2-pyrrolidinone (CAS: 872-50-4)?

1-Methyl-2-pyrrolidinone (NMP) is primarily used as a solvent in pharmaceuticals, where it aids in the formulation of drugs and extraction of active ingredients. It serves as a key component in coatings, inks, and adhesives due to its excellent solvating ability and film-forming properties. In the food industry, NMP acts as a stabilizer and emulsifier, enhancing product quality. Additionally, it is employed in lithium battery electrolytes and polymer synthesis. NMP’s versatility makes it indispensable in research and industrial applications, including chemical manufacturing and analytical processes. Its high boiling point and low volatility also contribute to its effectiveness in these uses.

Is 1-Methyl-2-pyrrolidinone (CAS: 872-50-4) safe?

1-Methyl-2-pyrrolidinone (NMP) is generally considered safe when handled properly, but it requires adherence to safety protocols. It is classified as a potential irritant, with possible effects on the skin, eyes, and respiratory system. Prolonged exposure may cause dermatitis or mucous membrane irritation, so protective measures like gloves, goggles, and ventilation are essential. According to OSHA and EPA guidelines, NMP should be stored and used in well-ventilated areas to minimize health risks. While not classified as a carcinogen, it is important to follow safety standards to ensure safe handling in industrial and laboratory settings.

How should 1-Methyl-2-pyrrolidinone (CAS: 872-50-4) be stored?

1-Methyl-2-pyrrolidinone (NMP) should be stored in a cool, dry place, ideally below 30°C, to maintain stability. It is sensitive to light and should be kept in dark, sealed containers to prevent degradation. Humidity control is crucial to avoid moisture absorption, which can affect its quality. NMP should be stored away from incompatible substances such as strong oxidizers or acids. Ensure the container is tightly closed and labeled properly. Proper storage conditions help preserve its chemical integrity and ensure safe handling. Always follow manufacturer guidelines and safety data sheets for optimal storage practices.