(3-Oxo-1,2,3,4-tetrahydro-2-quinoxalinyl)acetic acid
CAS Number:
136584-14-0
Molecular Formula:
C10H10N2O3
Synthesis and biological evaluation of S-lipidated lipopeptides of a connexin 43 channel inhibitory peptide
Literature Information
Publication Date
2020-07-10
DOI
10.1039/D0MD00172D
Impact Factor
0
Authors
Connor A. Clemett, Simon J. O'Carroll
View Original
Abstract
The synthesis and biological activity of 42 novel S-lipidated analogues of a connexin 43 channel inhibitory Peptide5 is described. Unmodified Peptide5 moderates hemichannels and gap junctions that are both implicated in the progression of neurological disease. Peptide5 was site-specifically modified with a cysteine residue, which then underwent thiol–ene mediated S-lipidation to afford S-lipidated Peptide5 analogues containing straight-chain, branched, or aromatic lipids. The modified peptides were assessed for their effect on hemichannel opening and the most promising candidates were evaluated in serum stability studies.
Related Literature
Electrochemistry of orthosilicate-based lithium battery cathodes: a perspective
Stefania Ferrari, Doretta Capsoni, Simone Casino, Matteo Destro, Claudio Gerbaldi, Marcella Bini
2014-04-15
Perspective
DOI: 10.1039/C4CP00511B
Towards chiral distributions of dopants in microporous frameworks: helicoidal supramolecular arrangement of (1R,2S)-ephedrine and transfer of chirality
Luis Gómez-Hortigüela, Teresa Álvaro-Muñoz, Beatriz Bernardo-Maestro, Joaquín Pérez-Pariente
2014-11-03
Paper
DOI: 10.1039/C4CP03957B
Interstellar H adsorption and H2 formation on the crystalline (010) forsterite surface: a B3LYP-D2* periodic study
Javier Navarro-Ruiz, Mariona Sodupe, Piero Ugliengo, Albert Rimola
2014-04-15
Paper
DOI: 10.1039/C4CP00819G
Unraveling manganese dissolution/deposition mechanisms on the negative electrode in lithium ion batteries
Xingcheng Xiao, Zhongyi Liu, Loïc Baggetto, Gabriel M. Veith, Karren L. More, Raymond R. Unocic
2014-04-03
Communication
DOI: 10.1039/C4CP00833B
Evaluation of fundamental transport properties of Li-excess garnet-type Li5+2xLa3Ta2−xYxO12 (x = 0.25, 0.5 and 0.75) electrolytes using AC impedance and dielectric spectroscopy
Ashok Kumar Baral, Sumaletha Narayanan, Farshid Ramezanipour, Venkataraman Thangadurai
2014-05-01
Paper
DOI: 10.1039/C4CP00418C
The homotropenylium cation: a system with a pinched π ring current
Mark Lillington, Patrick W. Fowler, Jon Baker, Leonardus W. Jenneskens
2014-04-25
Paper
DOI: 10.1039/C4CP01075B
Quantum study of boron nitride nanotubes functionalized with anticancer molecules
Eric Duverger, Tijani Gharbi, Eric Delabrousse, Fabien Picaud
2014-07-16
Paper
DOI: 10.1039/C4CP01660B
Conformational studies of poly(vinylidene fluoride), poly(trifluoroethylene) and poly(vinylidene fluoride-co-trifluoroethylene) using density functional theory
Martin Bohlén, Kim Bolton
2014-05-15
Paper
DOI: 10.1039/C4CP01012D
Warm white light generation from a single phase Dy3+ doped Mg2Al4Si5O18 phosphor for white UV-LEDs
Zhipeng Ci, Qisheng Sun, Shengchun Qin, Mengxing Sun, Xiaojing Jiang, Xudong Zhang, Yuhua Wang
2014-03-24
Paper
DOI: 10.1039/C4CP00357H
You might also like
Compound Q&A
What are the main uses of 1-(3-Aminophenyl)-3-[(3R)-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-(2-pyridinyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]urea (CAS: 155412-88-7)?
This compound is mainly used as an intermediate in the synthesis of antipsychoti...
155412-88-71-(3-Aminophenyl)-3-...
Compound Q&A
How should waste containing 1-(D-Ribofuranosyl)-1,4-dihydro-3-pyridinecarboxamide (CAS: 19132-12-8) be handled?
Waste containing 1-(D-Ribofuranosyl)-1,4-dihydro-3-pyridinecarboxamide (CAS: 191...
19132-12-81-(D-Ribofuranosyl)-...
Compound Q&A
What regulatory guidelines apply to 2-Methyl-2-propanyl 3-bromo-3-(hydroxymethyl)-1-azetidinecarboxylate (CAS: 2007919-81-3)?
2-Methyl-2-propanyl 3-bromo-3-(hydroxymethyl)-1-azetidinecarboxylate (CAS: 20079...
2007919-81-32-Methyl-2-propanyl ...
Compound Q&A
What is N-(4-Chloro-2-pyridinyl)acetamide (CAS: 245056-66-0)?
N-(4-Chloro-2-pyridinyl)acetamide (CAS: 245056-66-0) is a chemical compound with...
245056-66-0N-(4-Chloro-2-pyridi...
Compound Q&A
What is 5-Chloro-2-hydroxybenzoic acid (CAS: 321-14-2)?
5-Chloro-2-hydroxybenzoic acid, also known as 5-chlorosalicylic acid, is an arom...
321-14-25-Chloro-2-hydroxybe...
Compound Q&A
What precautions should be taken when handling 1,1-Dichloro-1-fluoroethane (CAS: 1717-00-6)?
When handling 1,1-Dichloro-1-fluoroethane (CAS: 1717-00-6), it is important to u...
1717-00-61,1-Dichloro-1-fluor...
Compound Q&A
What are the physical and chemical properties of Fmoc-(2S,3R)-3-phenylpyrrolidine-2-carboxylic acid (CAS: 281655-32-1)?
Fmoc-(2S,3R)-3-phenylpyrrolidine-2-carboxylic acid is a white crystalline solid ...
281655-32-1Fmoc-(2S,3R)-3-pheny...
Compound Q&A
What are the main uses of 4-Amino-5-bromo-2-pyridinecarboxylic acid (CAS: 1363381-01-4)?
4-Amino-5-bromo-2-pyridinecarboxylic acid is primarily used as a precursor in th...
1363381-01-44-Amino-5-bromo-2-py...
Compound Q&A
What precautions should be taken when handling (S)-tert-butyl 2-((2-(4-bromophenyl)-2-oxoethyl)carbamoyl)pyrrolidine-1-carboxylate (CAS: 1007881-98-2)?
Handling this compound should be done with personal protective equipment (PPE) i...
1007881-98-2(S)-tert-butyl 2-((2...
Compound Q&A
What precautions should be taken when handling 8-bromo-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one (CAS: 688363-73-7)?
When handling 8-bromo-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one, use prop...
688363-73-78-bromo-2,2-dimethyl...
Source Journal
Recommended Compounds
![Methyl 4-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)bicyclo[2.2.2]octane-1-carboxylate structure](https://static.chemtradehub.com/structs/943/943845-74-7-b7e5.webp "Methyl 4-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)bicyclo[2.2.2]octane-1-carboxylate structure")
Methyl 4-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)bicyclo[2.2.2]octane-1-carboxylate
CAS Number:
943845-74-7
Molecular Formula:
C15H25NO4
Recommended Suppliers
Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.