![5-Acetyl-2,3-dihydrobenzo[b]furan structure](https://static.chemtradehub.com/structs/908/90843-31-5-eea4.webp "5-Acetyl-2,3-dihydrobenzo[b]furan structure")
In vivo delivery of a fluorescent FPR2/ALX-targeted probe using focused ultrasound and microbubbles to image activated microglia
Literature Information
Publication Date
2020-09-23
DOI
10.1039/D0CB00140F
Impact Factor
0
Authors
Sophie V. Morse, Tamara Boltersdorf, Felicity N. E. Gavins, James J. Choi, Nicholas J. Long
View Original
Abstract
To image activated microglia, a small-molecule FPR2/ALX-targeted fluorescent probe was locally delivered into the brain using focused ultrasound and microbubbles. The probe did not co-localise with neurons or astrocytes but accumulated in activated microglia, making this a potential imaging tool for future drug discovery programs focused on neurological disorders.
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