Synthesis of paracyclophanes with planar and central chirality: kinetic resolution of [2.2]paracyclophane aldimines via palladium-catalyzed addition of arylboronic acids
Literature Information
Publication Date
2019-10-28
DOI
10.1039/C9QO01011D
Impact Factor
5.281
Authors
Han Wang, Bo Wu
View Original
Abstract
Kinetic resolution of [2.2]paracyclophane aldimines was achieved through palladium-catalyzed enantioselective arylation with arylboronic acids. The catalytic process provided reliable access to enantiopure paracyclophane derivatives with planar and central chirality as well as the recovered chiral aldimines with a selectivity factor up to 368. Furthermore, the synthetic utility of the [2.2]paracyclophane aldimines has been demonstrated by converting them into useful chiral building blocks.
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Organic Chemistry Frontiers
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